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brwd3 bromodomain and WD repeat domain containing 3 [ Danio rerio (zebrafish) ]

Gene ID: 553209, updated on 12-Sep-2024

Summary

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Official Symbol
brwd3provided by ZNC
Official Full Name
bromodomain and WD repeat domain containing 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-100921-43
See related
Ensembl:ENSDARG00000035540 AllianceGenome:ZFIN:ZDB-GENE-100921-43
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-237j10.3
Summary
Predicted to be involved in cytoskeleton organization; regulation of cell shape; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 93. Orthologous to human BRWD3 (bromodomain and WD repeat domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (22974033..23022018)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (22469764..22518232)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:ch211-26b3.4 Neighboring gene si:dkey-237j10.2 Neighboring gene high mobility group nucleosomal binding domain 7 Neighboring gene charged multivesicular body protein 1B Neighboring gene cyclic nucleotide gated channel subunit alpha 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function. Roberto VP, et al. Gene, 2015 Jul 15. PMID 25869932
  2. Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. Cosse-Etchepare C, et al. Int J Dev Biol, 2018. PMID 29877572
  3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bromodomain and WD repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    22974033..23022018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301410.4 → XP_009299685.1  bromodomain and WD repeat-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M3ASD3
    Conserved Domains (5) summary
    cd05496
    Location:1295 → 1413
    Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd05529
    Location:1127 → 1242
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    COG2319
    Location:176 → 541
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:173 → 495
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:184 → 221
    7WD40; WD40 repeat [structural motif]

  2. XM_009301411.4 → XP_009299686.1  bromodomain and WD repeat-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B2F0
    Related
    ENSDARP00000027753.11, ENSDART00000020434.11
    Conserved Domains (5) summary
    cd05496
    Location:1294 → 1412
    Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd05529
    Location:1126 → 1241
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    COG2319
    Location:176 → 541
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:173 → 495
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:184 → 221
    7WD40; WD40 repeat [structural motif]

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394574.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    201838..238195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471594.2 → XP_021327269.1  bromodomain and WD repeat-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PQW9
    Conserved Domains (4) summary
    cd05496
    Location:1295 → 1413
    Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd05529
    Location:1127 → 1242
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd00200
    Location:173 → 495
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:184 → 221
    7WD40; WD40 repeat [structural motif]

  2. XM_021471595.2 → XP_021327270.1  bromodomain and WD repeat-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q1J4
    Conserved Domains (4) summary
    cd05496
    Location:1294 → 1412
    Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd05529
    Location:1126 → 1241
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd00200
    Location:173 → 495
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:184 → 221
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
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