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PPP4C protein phosphatase 4 catalytic subunit [ Homo sapiens (human) ]

Gene ID: 5531, updated on 7-Apr-2024

Summary

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Official Symbol
PPP4Cprovided by HGNC
Official Full Name
protein phosphatase 4 catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:9319
See related
Ensembl:ENSG00000149923 MIM:602035; AllianceGenome:HGNC:9319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP4; PPX; PP-X; PP4C; PPH3; PPP4
Summary
Enables protein serine/threonine phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 31.5), placenta (RPKM 25.7) and 25 other tissues See more
Orthologs
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Genomic context

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See PPP4C in Genome Data Viewer
Location:
16p11.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30075994..30085376)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30358641..30368019)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30087315..30096697)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromosome 16 open reading frame 92 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30039801-30040645 Neighboring gene TLC domain containing 3B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7348 Neighboring gene MPRA-validated peak2562 silencer Neighboring gene uncharaterized LOC112694756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30064875-30065853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30065854-30066831 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30076132-30076912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7350 Neighboring gene aldolase, fructose-bisphosphate A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10689 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30096821-30096985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30101709-30102582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10690 Neighboring gene T-box transcription factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30107354-30107960 Neighboring gene yippee like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Loss of PP4 contributes to diesel exhaust particles-induced epithelial barrier integrity disruption and alarmins release. Yang FM, et al. Allergy, 2023 Jun. PMID 36458827
  2. PP4C facilitates lung cancer proliferation and inhibits apoptosis via activating MAPK/ERK pathway. Wang B, et al. Pathol Res Pract, 2020 May. PMID 32139257
  3. Protein phosphatase 4 catalytic subunit is overexpressed in glioma and promotes glioma cell proliferation and invasion. Li M, et al. Tumour Biol, 2016 Sep. PMID 27059736
  4. High expression of protein phosphatase 4 is associated with the aggressive malignant behavior of colorectal carcinoma. Li X, et al. Mol Cancer, 2015 Apr 28. PMID 25927939, Free PMC Article
  5. Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death. Theobald B, et al. Mol Cancer Res, 2013 Aug. PMID 23671329, Free PMC Article

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
    Title: DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
  2. Protein Phosphatase 4 Is Required for Centrobin Function in DNA Damage Repair.
    Title: Protein Phosphatase 4 Is Required for Centrobin Function in DNA Damage Repair.
  3. SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex.
    Title: SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex.
  4. Loss of PP4 contributes to diesel exhaust particles-induced epithelial barrier integrity disruption and alarmins release.
    Title: Loss of PP4 contributes to diesel exhaust particles-induced epithelial barrier integrity disruption and alarmins release.
  5. Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer.
    Title: Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer.
  6. PP4C facilitates lung cancer proliferation and inhibits apoptosis via activating MAPK/ERK pathway.
    Title: PP4C facilitates lung cancer proliferation and inhibits apoptosis via activating MAPK/ERK pathway.
  7. Sciatic nerve but not spinal injury induces calcium-dependent PP4 activity that is required for HDAC3 dephosphorylation.
    Title: PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure.
  8. PP4 regulates breast cancer cell survival and identifies a novel PP4c-PEA15 signalling axis in the control of breast cancer cell survival.
    Title: The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells.
  9. Knockdown of Alpha4 preferentially impacts the expression of PP4c and PP6c compared to expression levels of PP2Ac.
    Title: The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4.
  10. Data show that protein phosphatase 4 catalytic subunit (PP4C) knockdown decreases glioma cell proliferation.
    Title: Protein phosphatase 4 catalytic subunit is overexpressed in glioma and promotes glioma cell proliferation and invasion.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
part_of protein phosphatase 4 complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein phosphatase 4 catalytic subunit
Names
epididymis secretory sperm binding protein
protein phosphatase 4 (formerly X), catalytic subunit
protein phosphatase X, catalytic subunit
NP_001290432.1
NP_001290433.1
NP_001290435.1
NP_001290436.1
NP_002711.1
XP_006721124.1
XP_054169384.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303503.2 → NP_001290432.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_001290432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA765831, AF097996, BC001416, BG705710
    Consensus CDS
    CCDS10669.1
    UniProtKB/Swiss-Prot
    P33172, P60510
    UniProtKB/TrEMBL
    A0A024R625, Q5U086
    Conserved Domains (1) summary
    cd07415
    Location:6 → 290
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

  2. NM_001303504.2 → NP_001290433.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 2

    See identical proteins and their annotated locations for NP_001290433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AA765831, AF097996, BG705710, BQ220878
    UniProtKB/TrEMBL
    H3BTA2
    Related
    ENSP00000457089.1, ENST00000562664.5
    Conserved Domains (1) summary
    cd07415
    Location:6 → 256
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

  3. NM_001303506.2 → NP_001290435.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 3

    See identical proteins and their annotated locations for NP_001290435.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate splice site in an internal exon and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Both variants 4 and 5 encode the same isoform (3).
    Source sequence(s)
    AA765831, AF097996, BG705710, BG741669
    UniProtKB/TrEMBL
    H3BTA2
    Conserved Domains (1) summary
    cd07415
    Location:1 → 211
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

  4. NM_001303507.2 → NP_001290436.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 3

    See identical proteins and their annotated locations for NP_001290436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks an alternate internal exon and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Both variants 4 and 5 encode the same isoform (3).
    Source sequence(s)
    AA765831, AF097996, AL519181, BG706310
    UniProtKB/TrEMBL
    H3BTA2
    Conserved Domains (1) summary
    cd07415
    Location:1 → 211
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

  5. NM_002720.3 → NP_002711.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_002711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA765831, AF097996, BG705710
    Consensus CDS
    CCDS10669.1
    UniProtKB/Swiss-Prot
    P33172, P60510
    UniProtKB/TrEMBL
    A0A024R625, Q5U086
    Related
    ENSP00000279387.7, ENST00000279387.12
    Conserved Domains (1) summary
    cd07415
    Location:6 → 290
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    30075994..30085376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721061.5 → XP_006721124.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X1

    See identical proteins and their annotated locations for XP_006721124.1

    UniProtKB/TrEMBL
    H3BTA2
    Conserved Domains (1) summary
    cd07415
    Location:6 → 256
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    30358641..30368019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313409.1 → XP_054169384.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60510.1 GenPept UniProtKB/Swiss-Prot:P60510

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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