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PPP4C protein phosphatase 4 catalytic subunit [ Homo sapiens (human) ]

Gene ID: 5531, updated on 31-Dec-2019

Summary

Official Symbol
PPP4Cprovided by HGNC
Official Full Name
protein phosphatase 4 catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:9319
See related
Ensembl:ENSG00000149923 MIM:602035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP4; PPX; PP-X; PP4C; PPH3; PPP4
Expression
Ubiquitous expression in testis (RPKM 31.5), placenta (RPKM 25.7) and 25 other tissues See more
Orthologs

Genomic context

See PPP4C in Genome Data Viewer
Location:
16p11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (30075994..30085377)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30087297..30096698)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromosome 16 open reading frame 92 Neighboring gene TLC domain containing 3B Neighboring gene uncharaterized LOC112694756 Neighboring gene aldolase, fructose-bisphosphate A Neighboring gene T-box transcription factor 6 Neighboring gene yippee like 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NF-kappaB-inducing kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
protein phosphatase 4 complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 4 catalytic subunit
Names
epididymis secretory sperm binding protein
protein phosphatase 4 (formerly X), catalytic subunit
protein phosphatase X, catalytic subunit
NP_001290432.1
NP_001290433.1
NP_001290435.1
NP_001290436.1
NP_002711.1
XP_006721124.1
XP_016878892.1
XP_016878893.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303503.2NP_001290432.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_001290432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA765831, AF097996, BC001416, BG705710
    Consensus CDS
    CCDS10669.1
    UniProtKB/Swiss-Prot
    P60510
    UniProtKB/TrEMBL
    A0A024R625
    Conserved Domains (1) summary
    cd07415
    Location:6290
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  2. NM_001303504.2NP_001290433.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 2

    See identical proteins and their annotated locations for NP_001290433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AA765831, AF097996, BG705710, BQ220878
    UniProtKB/Swiss-Prot
    P60510
    Related
    ENSP00000457089.1, ENST00000562664.5
    Conserved Domains (1) summary
    cd07415
    Location:6256
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  3. NM_001303506.2NP_001290435.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 3

    See identical proteins and their annotated locations for NP_001290435.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate splice site in an internal exon and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Both variants 4 and 5 encode the same isoform (3).
    Source sequence(s)
    AA765831, AF097996, BG705710, BG741669
    UniProtKB/Swiss-Prot
    P60510
    Conserved Domains (1) summary
    cd07415
    Location:1211
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  4. NM_001303507.2NP_001290436.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 3

    See identical proteins and their annotated locations for NP_001290436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks an alternate internal exon and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Both variants 4 and 5 encode the same isoform (3).
    Source sequence(s)
    AA765831, AF097996, AL519181, BG706310
    UniProtKB/Swiss-Prot
    P60510
    Conserved Domains (1) summary
    cd07415
    Location:1211
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  5. NM_002720.3NP_002711.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_002711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA765831, AF097996, BG705710
    Consensus CDS
    CCDS10669.1
    UniProtKB/Swiss-Prot
    P60510
    UniProtKB/TrEMBL
    A0A024R625
    Related
    ENSP00000279387.7, ENST00000279387.12
    Conserved Domains (1) summary
    cd07415
    Location:6290
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    30075994..30085377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721061.4XP_006721124.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X1

    See identical proteins and their annotated locations for XP_006721124.1

    Conserved Domains (1) summary
    cd07415
    Location:6256
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  2. XM_017023404.1XP_016878893.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X2

    Conserved Domains (1) summary
    cd07415
    Location:1211
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  3. XM_017023403.1XP_016878892.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X2

    Conserved Domains (1) summary
    cd07415
    Location:1211
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
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