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PPP4C protein phosphatase 4 catalytic subunit [ Homo sapiens (human) ]

Gene ID: 5531, updated on 5-Nov-2017
Official Symbol
PPP4Cprovided by HGNC
Official Full Name
protein phosphatase 4 catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:9319
See related
Ensembl:ENSG00000149923 MIM:602035; Vega:OTTHUMG00000132113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP4; PPX; PP-X; PP4C; PPH3; PPP4
Orthologs
Location:
16p11.2
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (30075976..30085377)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30087297..30096698)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromosome 16 open reading frame 92 Neighboring gene family with sequence similarity 57 member B Neighboring gene aldolase, fructose-bisphosphate A Neighboring gene T-box 6 Neighboring gene yippee like 3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • DNA Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
    DNA Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Glucagon signaling pathway, organism-specific biosystem (from KEGG)
    Glucagon signaling pathway, organism-specific biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Glucagon signaling pathway, conserved biosystem (from KEGG)
    Glucagon signaling pathway, conserved biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystem (from REACTOME)
    HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystemHomology directed repair (HDR) of replication-independent DNA double strand breaks (DSBs) via homologous recombination repair (HRR) or single strand annealing (SSA) requires the activation of ATM fol...
  • Homology Directed Repair, organism-specific biosystem (from REACTOME)
    Homology Directed Repair, organism-specific biosystemHomology directed repair (HDR) of DNA double strand breaks (DSBs) requires resection of DNA DSB ends. Resection creates 3'-ssDNA overhangs which then anneal with a homologous DNA sequence. This homol...
  • Processing of DNA double-strand break ends, organism-specific biosystem (from REACTOME)
    Processing of DNA double-strand break ends, organism-specific biosystemHomology directed repair (HDR) through homologous recombination (HRR) or single strand annealing (SSA) requires extensive resection of DNA double strand break (DSB) ends (Thompson and Limoli 2003, Ci...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NF-kappaB-inducing kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
protein phosphatase 4 complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
serine/threonine-protein phosphatase 4 catalytic subunit
Names
protein phosphatase 4 (formerly X), catalytic subunit
protein phosphatase X, catalytic subunit
NP_001290432.1
NP_001290433.1
NP_001290435.1
NP_001290436.1
NP_002711.1
XP_006721124.1
XP_016878892.1
XP_016878893.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303503.1NP_001290432.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_001290432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA765831, AF097996, BC001416, BG705710
    Consensus CDS
    CCDS10669.1
    UniProtKB/Swiss-Prot
    P60510
    UniProtKB/TrEMBL
    A0A024R625
    Conserved Domains (1) summary
    cd07415
    Location:6290
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  2. NM_001303504.1NP_001290433.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 2

    See identical proteins and their annotated locations for NP_001290433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AA765831, AF097996, BG705710, BQ220878
    UniProtKB/Swiss-Prot
    P60510
    Related
    ENSP00000457089.1, OTTHUMP00000255864, ENST00000562664.5, OTTHUMT00000435393
    Conserved Domains (1) summary
    cd07415
    Location:6256
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  3. NM_001303506.1NP_001290435.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 3

    See identical proteins and their annotated locations for NP_001290435.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate splice site in an internal exon and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Both variants 4 and 5 encode the same isoform (3).
    Source sequence(s)
    AA765831, AF097996, BG705710, BG741669
    UniProtKB/Swiss-Prot
    P60510
    Conserved Domains (1) summary
    cd07415
    Location:1211
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  4. NM_001303507.1NP_001290436.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 3

    See identical proteins and their annotated locations for NP_001290436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks an alternate internal exon and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Both variants 4 and 5 encode the same isoform (3).
    Source sequence(s)
    AA765831, AF097996, AL519181, BG705710, BG706310
    UniProtKB/Swiss-Prot
    P60510
    Conserved Domains (1) summary
    cd07415
    Location:1211
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  5. NM_002720.2NP_002711.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_002711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA765831, AF097996, BG705710
    Consensus CDS
    CCDS10669.1
    UniProtKB/Swiss-Prot
    P60510
    UniProtKB/TrEMBL
    A0A024R625
    Related
    ENSP00000279387.7, OTTHUMP00000162993, ENST00000279387.11, OTTHUMT00000255155
    Conserved Domains (1) summary
    cd07415
    Location:6290
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

    Range
    30075976..30085377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721061.3XP_006721124.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X1

    See identical proteins and their annotated locations for XP_006721124.1

    Conserved Domains (1) summary
    cd07415
    Location:6256
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  2. XM_017023404.1XP_016878893.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X2

    Conserved Domains (1) summary
    cd07415
    Location:1211
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  3. XM_017023403.1XP_016878892.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X2

    Conserved Domains (1) summary
    cd07415
    Location:1211
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    31303054..31312455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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