U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ppp4c protein phosphatase 4, catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 56420, updated on 12-May-2024

Summary

Official Symbol
Ppp4cprovided by MGI
Official Full Name
protein phosphatase 4, catalytic subunitprovided by MGI
Primary source
MGI:MGI:1891763
See related
Ensembl:ENSMUSG00000030697 AllianceGenome:MGI:1891763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ppx; pp4; PP-X; PP4C; 1110002D08Rik
Summary
Predicted to enable lamin binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in dephosphorylation and regulation of double-strand break repair via homologous recombination. Located in cytoplasm and nucleus. Part of protein phosphatase 4 complex. Is expressed in several structures, including brain; neural retina; olfactory epithelium; and thymus primordium. Orthologous to human PPP4C (protein phosphatase 4 catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 94.8), CNS E11.5 (RPKM 74.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ppp4c in Genome Data Viewer
Location:
7 F3; 7 69.25 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126385038..126391729, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126785866..126792557, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6602 Neighboring gene yippee like 3 Neighboring gene T-box 6 Neighboring gene STARR-positive B cell enhancer ABC_E6603 Neighboring gene predicted gene, 57854 Neighboring gene STARR-positive B cell enhancer ABC_E10476 Neighboring gene aldolase A, fructose-bisphosphate Neighboring gene TLC domain containing 3B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lamin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein phosphatase 4 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein phosphatase 4 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 4 catalytic subunit
Names
protein phosphatase X
NP_001347393.1
NP_062648.1
XP_006508112.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360464.1NP_001347393.1  serine/threonine-protein phosphatase 4 catalytic subunit

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS21844.1
    UniProtKB/Swiss-Prot
    P97470
    UniProtKB/TrEMBL
    Q3UNF2
    Related
    ENSMUSP00000146245.2, ENSMUST00000206570.2
    Conserved Domains (1) summary
    cd07415
    Location:6290
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
  2. NM_019674.4NP_062648.1  serine/threonine-protein phosphatase 4 catalytic subunit

    See identical proteins and their annotated locations for NP_062648.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS21844.1
    UniProtKB/Swiss-Prot
    P97470
    UniProtKB/TrEMBL
    Q3UNF2
    Related
    ENSMUSP00000032936.7, ENSMUST00000032936.8
    Conserved Domains (1) summary
    cd07415
    Location:6290
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126385038..126391729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508049.2XP_006508112.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X1

    See identical proteins and their annotated locations for XP_006508112.1

    Conserved Domains (1) summary
    cd07415
    Location:1211
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain