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RNF121 ring finger protein 121 [ Homo sapiens (human) ]

Gene ID: 55298, updated on 1-Jun-2020

Summary

Official Symbol
RNF121provided by HGNC
Official Full Name
ring finger protein 121provided by HGNC
Primary source
HGNC:HGNC:21070
See related
Ensembl:ENSG00000137522
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in kidney (RPKM 7.3), thyroid (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See RNF121 in Genome Data Viewer
Location:
11q13.4
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (71928701..71997597)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71639768..71708643)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene XRCC1 N-terminal domain containing 1-like Neighboring gene olfactory receptor family 7 subfamily E member 128 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 126 pseudogene Neighboring gene uncharacterized LOC100128494 Neighboring gene interleukin 18 binding protein Neighboring gene nuclear mitotic apparatus protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11099

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300926.1NP_001287855.1  RING finger protein 121 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has shorter and distinct N- and C-termini compared to isoform a.
    Source sequence(s)
    AL833638, AP002490, DA209781
    Consensus CDS
    CCDS73343.1
    UniProtKB/TrEMBL
    C9JQY5
    Related
    ENSP00000377316.3, ENST00000393713.7
  2. NM_018320.5NP_060790.2  RING finger protein 121 isoform a

    See identical proteins and their annotated locations for NP_060790.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AI291325, AK023139, AL833638, AP002490, CN392009, DA209781
    Consensus CDS
    CCDS8203.1
    UniProtKB/Swiss-Prot
    Q9H920
    Related
    ENSP00000354571.3, ENST00000361756.8
    Conserved Domains (1) summary
    cd16475
    Location:224278
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

RNA

  1. NR_024147.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an internal coding exon compared to transcript variant 1. If translation initiates at the same codon as used in variant 1, then this results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). Although a putative alternate AUG site is observed in a different frame downstream of the standard AUG site, it is not likely to be used because it is located within the short ORF available with the standard AUG site (as defined by variant 1). Therefore, the transcript is represented as a non-protein-coding RefSeq.
    Source sequence(s)
    AI291325, AK023139, AL833638, AP002490, CN392009, DA209781
    Related
    ENST00000530137.1
  2. NR_024148.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing an internal coding exon and also includes an additional exon compared to transcript variant 1. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). There are no other likely translation initiation sites and so the transcript is represented as a non-protein-coding RefSeq.
    Source sequence(s)
    AI291325, AK023139, AK094508, AL833638, AP002490, CN392009, DA209781, DA694800
    Related
    ENST00000526549.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    71928701..71997597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718629.1XP_006718692.1  RING finger protein 121 isoform X1

    See identical proteins and their annotated locations for XP_006718692.1

    Conserved Domains (1) summary
    pfam13639
    Location:190240
    zf-RING_2; Ring finger domain
  2. XM_006718632.1XP_006718695.1  RING finger protein 121 isoform X3

    See identical proteins and their annotated locations for XP_006718695.1

    Conserved Domains (1) summary
    pfam13639
    Location:119169
    zf-RING_2; Ring finger domain
  3. XM_011545150.1XP_011543452.1  RING finger protein 121 isoform X2

    See identical proteins and their annotated locations for XP_011543452.1

    UniProtKB/Swiss-Prot
    Q9H920
    Conserved Domains (1) summary
    pfam13639
    Location:145195
    zf-RING_2; Ring finger domain
  4. XM_006718630.1XP_006718693.1  RING finger protein 121 isoform X2

    See identical proteins and their annotated locations for XP_006718693.1

    UniProtKB/Swiss-Prot
    Q9H920
    Conserved Domains (1) summary
    pfam13639
    Location:145195
    zf-RING_2; Ring finger domain
  5. XM_024448604.1XP_024304372.1  RING finger protein 121 isoform X4

    Conserved Domains (1) summary
    cd16475
    Location:96150
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_194452.1: Suppressed sequence

    Description
    NM_194452.1: This RefSeq was permanently suppressed because it was annotated with an overlapping downstream ORF when an upstream ORF existed. However, use of the upstream AUG will render this transcript susceptible to nonsense-mediated mRNA decay (NMD).
  2. NM_194453.1: Suppressed sequence

    Description
    NM_194453.1: This RefSeq was permanently suppressed because it was annotated with an overlapping downstream ORF when an upstream ORF existed. However, use of the upstream AUG will render this transcript susceptible to nonsense-mediated mRNA decay (NMD).
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