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Rnf121 ring finger protein 121 [ Mus musculus (house mouse) ]

Gene ID: 75212, updated on 12-May-2024

Summary

Official Symbol
Rnf121provided by MGI
Official Full Name
ring finger protein 121provided by MGI
Primary source
MGI:MGI:1922462
See related
Ensembl:ENSMUSG00000070426 AllianceGenome:MGI:1922462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930544L10Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human RNF121 (ring finger protein 121). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 13.4), large intestine adult (RPKM 13.2) and 28 other tissues See more
Orthologs
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Genomic context

See Rnf121 in Genome Data Viewer
Location:
7 E2; 7 54.71 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101668344..101721712, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102019137..102072437, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8193 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene MYST histone acetyltransferase 1 pseudogene Neighboring gene predicted gene, 39061 Neighboring gene interleukin 18 binding protein Neighboring gene STARR-seq mESC enhancer starr_19703 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2 Neighboring gene ADP-ribosyltransferase 5 Neighboring gene ADP-ribosyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin ligase Rnf121
NP_001347677.1
NP_083487.2
XP_006508338.1
XP_030098907.1
XP_030098908.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360748.1NP_001347677.1  E3 ubiquitin ligase Rnf121 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC150275, AC167240, BE946466
    Conserved Domains (1) summary
    cd16475
    Location:70124
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins
  2. NM_029211.3NP_083487.2  E3 ubiquitin ligase Rnf121 isoform 1

    See identical proteins and their annotated locations for NP_083487.2

    Status: VALIDATED

    Source sequence(s)
    AC167240, AK159260, BE946466, BY316785
    Consensus CDS
    CCDS21523.1
    UniProtKB/Swiss-Prot
    Q3TXH5, Q8BP06, Q8BSB1, Q8R1Z9, Q9D4X4
    UniProtKB/TrEMBL
    Q3TXY7
    Related
    ENSMUSP00000094396.6, ENSMUST00000096639.12
    Conserved Domains (1) summary
    cd16475
    Location:224278
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101668344..101721712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508275.4XP_006508338.1  E3 ubiquitin ligase Rnf121 isoform X1

    See identical proteins and their annotated locations for XP_006508338.1

    UniProtKB/TrEMBL
    Q3TXY7
    Conserved Domains (2) summary
    cd16475
    Location:212266
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins
    cl28910
    Location:44200
    MFS; Major Facilitator Superfamily
  2. XM_030243047.2XP_030098907.1  E3 ubiquitin ligase Rnf121 isoform X2

    UniProtKB/TrEMBL
    K4DI70, Q3TXY7
    Related
    ENSMUSP00000086453.5, ENSMUST00000089052.11
    Conserved Domains (1) summary
    cd16475
    Location:201255
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins
  3. XM_030243048.2XP_030098908.1  E3 ubiquitin ligase Rnf121 isoform X3

    Conserved Domains (1) summary
    cd16475
    Location:70124
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins