U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rnf121 ring finger protein 121 [ Mus musculus (house mouse) ]

Gene ID: 75212, updated on 18-Mar-2023

Summary

Go to the top of the page Help
Official Symbol
Rnf121provided by MGI
Official Full Name
ring finger protein 121provided by MGI
Primary source
MGI:MGI:1922462
See related
Ensembl:ENSMUSG00000070426 AllianceGenome:MGI:1922462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930544L10Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human RNF121 (ring finger protein 121). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 13.4), large intestine adult (RPKM 13.2) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rnf121 in Genome Data Viewer
Location:
7; 7 E2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101668344..101721712, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102019137..102072437, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene MYST histone acetyltransferase 1 pseudogene Neighboring gene predicted gene, 39061 Neighboring gene interleukin 18 binding protein Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2 Neighboring gene ADP-ribosyltransferase 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The E3 ubiquitin ligase RNF121 is a positive regulator of NF-κB activation. Zemirli N, et al. Cell Commun Signal, 2014 Nov 12. PMID 25388546, Free PMC Article
  2. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (26) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin ligase Rnf121; RING finger protein 121
NP_001347677.1
NP_083487.2
XP_006508338.1
XP_030098907.1
XP_030098908.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360748.1 → NP_001347677.1  E3 ubiquitin ligase Rnf121 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC150275, AC167240, BE946466
    UniProtKB/TrEMBL
    A0A6P7RDK2
    Conserved Domains (1) summary
    cd16475
    Location:70 → 124
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

  2. NM_029211.3 → NP_083487.2  E3 ubiquitin ligase Rnf121 isoform 1

    See identical proteins and their annotated locations for NP_083487.2

    Status: VALIDATED

    Source sequence(s)
    AC167240, AK159260, BE946466, BY316785
    Consensus CDS
    CCDS21523.1
    UniProtKB/Swiss-Prot
    Q8R1Z9, Q9D4X4
    UniProtKB/TrEMBL
    A0A6P5Q4G9
    Related
    ENSMUSP00000094396.6, ENSMUST00000096639.12
    Conserved Domains (1) summary
    cd16475
    Location:224 → 278
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101668344..101721712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508275.4 → XP_006508338.1  RING finger protein 121 isoform X1

    See identical proteins and their annotated locations for XP_006508338.1

    UniProtKB/Swiss-Prot
    Q8R1Z9
    Conserved Domains (2) summary
    cd16475
    Location:212 → 266
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins
    cl28910
    Location:44 → 200
    MFS; Major Facilitator Superfamily

  2. XM_030243047.2 → XP_030098907.1  RING finger protein 121 isoform X2

    UniProtKB/TrEMBL
    A0A6P5Q6Z4, K4DI70
    Related
    ENSMUSP00000086453.5, ENSMUST00000089052.11
    Conserved Domains (1) summary
    cd16475
    Location:201 → 255
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

  3. XM_030243048.2 → XP_030098908.1  RING finger protein 121 isoform X3

    UniProtKB/TrEMBL
    A0A6P7RDK2
    Conserved Domains (1) summary
    cd16475
    Location:70 → 124
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1Z9.1 GenPept UniProtKB/Swiss-Prot:Q8R1Z9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous