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KLHL26 kelch like family member 26 [ Homo sapiens (human) ]

Gene ID: 55295, updated on 23-Nov-2021

Summary

Official Symbol
KLHL26provided by HGNC
Official Full Name
kelch like family member 26provided by HGNC
Primary source
HGNC:HGNC:25623
See related
Ensembl:ENSG00000167487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 4.1), kidney (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See KLHL26 in Genome Data Viewer
Location:
19p13.11
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18637028..18671721)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18747838..18782531)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 59 like Neighboring gene RNA, 7SL, cytoplasmic 155, pseudogene Neighboring gene CREB regulated transcription coactivator 1 Neighboring gene cartilage oligomeric matrix protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11078

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
kelch-like protein 26
Names
kelch-like 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001345981.2NP_001332910.1  kelch-like protein 26 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC004476, AC008998
  2. NM_001345982.2NP_001332911.1  kelch-like protein 26 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC004476, AC008998
    Conserved Domains (2) summary
    sd00038
    Location:341388
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:54596
    BTB; Broad-Complex, Tramtrack and Bric a brac
  3. NM_001345983.2NP_001332912.1  kelch-like protein 26 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate first exon and an alternate splice junction compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC004476, AC008998
    Conserved Domains (4) summary
    PHA03098
    Location:27517
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:262309
    Kelch; KELCH repeat [structural motif]
    cd18465
    Location:70166
    BACK_KLHL26; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26)
    cl38908
    Location:175
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
  4. NM_001345984.2NP_001332913.1  kelch-like protein 26 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction and lacks a large segment of coding region compared to variant 1. The resulting isoform (5) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC004476, AC008998
    Consensus CDS
    CCDS86727.1
    UniProtKB/TrEMBL
    M0R1N0
    Related
    ENSP00000472001.1, ENST00000599006.5
    Conserved Domains (1) summary
    pfam00651
    Location:56136
    BTB; BTB/POZ domain
  5. NM_001345985.2NP_001332914.1  kelch-like protein 26 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC004476, AC008998
    Consensus CDS
    CCDS86726.1
    UniProtKB/TrEMBL
    M0R1P3
    Related
    ENSP00000472032.1, ENST00000595182.5
    Conserved Domains (1) summary
    cl38908
    Location:4599
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
  6. NM_018316.3NP_060786.1  kelch-like protein 26 isoform 2

    See identical proteins and their annotated locations for NP_060786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC004476, AK001940, BC026319, DA453727
    Consensus CDS
    CCDS12384.1
    UniProtKB/Swiss-Prot
    Q53HC5
    UniProtKB/TrEMBL
    A0A024R7N5
    Related
    ENSP00000300976.3, ENST00000300976.9
    Conserved Domains (4) summary
    PHA03098
    Location:65607
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:352399
    Kelch; KELCH repeat [structural motif]
    cd18255
    Location:45165
    BTB_POZ_KLHL26; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26)
    cd18465
    Location:160256
    BACK_KLHL26; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    18637028..18671721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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