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PPP2R5B protein phosphatase 2 regulatory subunit B'beta [ Homo sapiens (human) ]

Gene ID: 5526, updated on 13-Mar-2020

Summary

Official Symbol
PPP2R5Bprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit B'betaprovided by HGNC
Primary source
HGNC:HGNC:9310
See related
Ensembl:ENSG00000068971 MIM:601644
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B56B; PR61B; B56beta
Summary
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 15.1), gall bladder (RPKM 6.6) and 25 other tissues See more
Orthologs

Genomic context

See PPP2R5B in Genome Data Viewer
Location:
11q13.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64917553..64934478)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64692143..64701950)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene autophagy related 2A Neighboring gene microRNA 6750 Neighboring gene microRNA 6749 Neighboring gene glycoprotein hormone subunit alpha 2 Neighboring gene membrane anchored junction protein Neighboring gene basic leucine zipper ATF-like transcription factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35411

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G0 to G1 transition IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neurotrophin TRK receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein complex assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
Names
PP2A B subunit isoform B'-beta
PP2A B subunit isoform B56-beta
PP2A B subunit isoform PR61-beta
PP2A B subunit isoform R5-beta
protein phosphatase 2 regulatory subunit B', beta
protein phosphatase 2, regulatory subunit B', beta isoform

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046897.1 RefSeqGene

    Range
    12137..21923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006244.4NP_006235.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

    See identical proteins and their annotated locations for NP_006235.1

    Status: REVIEWED

    Source sequence(s)
    AP001187, BE883575, BM665417, L42374
    Consensus CDS
    CCDS8085.1
    UniProtKB/Swiss-Prot
    Q15173
    UniProtKB/TrEMBL
    A0A024R593
    Related
    ENSP00000164133.2, ENST00000164133.7
    Conserved Domains (2) summary
    PLN00122
    Location:373467
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:69467
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64917553..64934478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545133.1XP_011543435.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X2

    See identical proteins and their annotated locations for XP_011543435.1

    Conserved Domains (2) summary
    PLN00122
    Location:287381
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:1381
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  2. XM_011545132.2XP_011543434.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1

    Conserved Domains (2) summary
    PLN00122
    Location:344438
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:40438
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  3. XM_011545134.3XP_011543436.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X2

    See identical proteins and their annotated locations for XP_011543436.1

    Conserved Domains (2) summary
    PLN00122
    Location:287381
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:1381
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
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