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LRRC1 leucine rich repeat containing 1 [ Homo sapiens (human) ]

Gene ID: 55227, updated on 21-Dec-2019

Summary

Official Symbol
LRRC1provided by HGNC
Official Full Name
leucine rich repeat containing 1provided by HGNC
Primary source
HGNC:HGNC:14307
See related
Ensembl:ENSG00000137269 MIM:608195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LANO; dJ523E19.1
Expression
Broad expression in colon (RPKM 4.5), thyroid (RPKM 3.0) and 23 other tissues See more
Orthologs

Genomic context

See LRRC1 in Genome Data Viewer
Location:
6p12.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (53794497..53924125)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (53659295..53789490)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11274 Neighboring gene kelch like family member 31 Neighboring gene uncharacterized LOC101927189 Neighboring gene MLIP intronic transcript 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10775, FLJ11834

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter receptor transport postsynaptic membrane to endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor localization to synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
colocalizes_with ionotropic glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat-containing protein 1
Names
LANO adapter protein
LAP (leucine-rich repeats and PDZ) and no PDZ protein
LAP and no PDZ protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018214.5NP_060684.4  leucine-rich repeat-containing protein 1

    See identical proteins and their annotated locations for NP_060684.4

    Status: VALIDATED

    Source sequence(s)
    AL033384, BC003193
    Consensus CDS
    CCDS4953.2
    UniProtKB/Swiss-Prot
    Q9BTT6
    Related
    ENSP00000359925.1, ENST00000370888.6
    Conserved Domains (3) summary
    cd00116
    Location:33232
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6183
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:129186
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    53794497..53924125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514726.2XP_011513028.1  leucine-rich repeat-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011513028.1

    UniProtKB/Swiss-Prot
    Q9BTT6
    Conserved Domains (3) summary
    cd00116
    Location:33232
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6183
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:129186
    LRR_8; Leucine rich repeat
  2. XM_017010997.1XP_016866486.1  leucine-rich repeat-containing protein 1 isoform X3

  3. XM_011514727.2XP_011513029.1  leucine-rich repeat-containing protein 1 isoform X2

    Conserved Domains (2) summary
    sd00033
    Location:4870
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:70127
    LRR_8; Leucine rich repeat

RNA

  1. XR_001743504.1 RNA Sequence

  2. XR_001743505.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025168.1: Suppressed sequence

    Description
    NM_025168.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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