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NKAPD1 NKAP domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55216, updated on 4-Jul-2021

Summary

Official Symbol
NKAPD1provided by HGNC
Official Full Name
NKAP domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25569
See related
Ensembl:ENSG00000150776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11orf57
Expression
Ubiquitous expression in thyroid (RPKM 9.5), brain (RPKM 8.4) and 25 other tissues See more
Orthologs
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Genomic context

See NKAPD1 in Genome Data Viewer
Location:
11q23.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (112074299..112085150)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111945023..111955874)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 893, pseudogene Neighboring gene dihydrolipoamide S-acetyltransferase Neighboring gene PIH1 domain containing 2 Neighboring gene translocase of inner mitochondrial membrane 8 homolog B Neighboring gene succinate dehydrogenase complex subunit D Neighboring gene interleukin 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10726

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
uncharacterized protein NKAPD1
Names
NKAP domain containing protein 1
uncharacterized protein C11orf57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082969.2NP_001076438.1  uncharacterized protein NKAPD1 isoform a

    See identical proteins and their annotated locations for NP_001076438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AB096251, BM670479, CD706604
    Consensus CDS
    CCDS8356.2
    UniProtKB/TrEMBL
    A0A024R3H5
    Conserved Domains (1) summary
    pfam15692
    Location:86147
    NKAP; NF-kappa-B-activating protein
  2. NM_001082970.2NP_001076439.1  uncharacterized protein NKAPD1 isoform b

    See identical proteins and their annotated locations for NP_001076439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal aa, compared to isoform a.
    Source sequence(s)
    AK125340, AP002007, BM670479, EL736728
    Consensus CDS
    CCDS41715.1
    UniProtKB/Swiss-Prot
    Q6ZUT1
    Related
    ENSP00000339076.7, ENST00000280352.13
    Conserved Domains (1) summary
    pfam15692
    Location:86146
    NKAP; NF-kappa-B-activating protein
  3. NM_001301017.2NP_001287946.1  uncharacterized protein NKAPD1 isoform b

    See identical proteins and their annotated locations for NP_001287946.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 5 both encode the same isoform (b).
    Source sequence(s)
    AP002007, BC072455, BX538107, CD706604
    Consensus CDS
    CCDS41715.1
    UniProtKB/Swiss-Prot
    Q6ZUT1
    Related
    ENSP00000402208.2, ENST00000420986.6
    Conserved Domains (1) summary
    pfam15692
    Location:86146
    NKAP; NF-kappa-B-activating protein
  4. NM_001301019.2NP_001287948.1  uncharacterized protein NKAPD1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice junction at the 3' end of an exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AP002007, BX538107, CD244552, CD706604
    Consensus CDS
    CCDS73383.1
    UniProtKB/Swiss-Prot
    Q6ZUT1
    Related
    ENSP00000435408.1, ENST00000525785.5
    Conserved Domains (1) summary
    pfam15692
    Location:57118
    NKAP; NF-kappa-B-activating protein
  5. NM_001301021.2NP_001287950.1  uncharacterized protein NKAPD1 isoform d

    See identical proteins and their annotated locations for NP_001287950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice junction at the 3' end of an exon and an alternate in-frame exon at the 5' end of the last exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks a single internal aa compared to isoform a.
    Source sequence(s)
    AP002007, BX538107, DA813095
    UniProtKB/Swiss-Prot
    Q6ZUT1
    Conserved Domains (1) summary
    pfam15692
    Location:56117
    NKAP; NF-kappa-B-activating protein
  6. NM_018195.4NP_060665.3  uncharacterized protein NKAPD1 isoform a

    See identical proteins and their annotated locations for NP_060665.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 both encode the same isoform (a).
    Source sequence(s)
    AP002007, BG115155, BM670479, CD706604, DT220380
    Consensus CDS
    CCDS8356.2
    UniProtKB/TrEMBL
    A0A024R3H5
    Related
    ENSP00000376767.3, ENST00000393047.8
    Conserved Domains (1) summary
    pfam15692
    Location:86147
    NKAP; NF-kappa-B-activating protein

RNA

  1. NR_103469.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an additional segment in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB096251, BX538107, CD244552

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    112074299..112085150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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