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LGI2 leucine rich repeat LGI family member 2 [ Homo sapiens (human) ]

Gene ID: 55203, updated on 10-Oct-2020

Summary

Official Symbol
LGI2provided by HGNC
Official Full Name
leucine rich repeat LGI family member 2provided by HGNC
Primary source
HGNC:HGNC:18710
See related
Ensembl:ENSG00000153012 MIM:608301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LGIL2
Expression
Broad expression in gall bladder (RPKM 3.7), appendix (RPKM 3.2) and 20 other tissues See more
Orthologs

Genomic context

See LGI2 in Genome Data Viewer
Location:
4p15.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (24991960..25030946, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (25000471..25032414, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 149 Neighboring gene superoxide dismutase 3 Neighboring gene uncharacterized LOC102723675 Neighboring gene uncharacterized LOC105374534 Neighboring gene Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • FLJ10675, KIAA1916, MGC126808, MGC126810

Gene Ontology Provided by GOA

Process Evidence Code Pubs
inhibitory synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leucine-rich repeat LGI family member 2
Names
LGI1-like protein 2
leucine-rich glioma-inactivated protein 2
leucine-rich, glioma inactivated 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018176.4NP_060646.2  leucine-rich repeat LGI family member 2 precursor

    See identical proteins and their annotated locations for NP_060646.2

    Status: VALIDATED

    Source sequence(s)
    AC113614, BC101761
    Consensus CDS
    CCDS3431.1
    UniProtKB/Swiss-Prot
    Q8N0V4
    Related
    ENSP00000371548.4, ENST00000382114.9
    Conserved Domains (4) summary
    TIGR00864
    Location:140215
    PCC; polycystin cation channel protein
    sd00031
    Location:111134
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:110169
    LRR_8; Leucine rich repeat
    pfam03736
    Location:266305
    EPTP; EPTP domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    24991960..25030946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008356.1XP_016863845.1  leucine-rich repeat LGI family member 2 isoform X2

  2. XM_011513850.2XP_011512152.1  leucine-rich repeat LGI family member 2 isoform X1

    Conserved Domains (5) summary
    sd00031
    Location:111134
    LRR_1; leucine-rich repeat [structural motif]
    pfam03736
    Location:219260
    EPTP; EPTP domain
    pfam12799
    Location:110149
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:110169
    LRR_8; Leucine rich repeat
    cl15307
    Location:167212
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
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