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DZANK1 double zinc ribbon and ankyrin repeat domains 1 [ Homo sapiens (human) ]

Gene ID: 55184, updated on 23-Nov-2021

Summary

Official Symbol
DZANK1provided by HGNC
Official Full Name
double zinc ribbon and ankyrin repeat domains 1provided by HGNC
Primary source
HGNC:HGNC:15858
See related
Ensembl:ENSG00000089091
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANKRD64; C20orf12; C20orf84
Summary
This gene contains two ankyrin repeat-encoding regions. Ankyrin repeats are tandemly repeated modules of about 33 amino acids described as L-shaped structures consisting of a beta-hairpin and two alpha-helices. Ankyrin repeats occur in a large number of functionally diverse proteins, mainly from eukaryotes, and are known to function as protein-protein interaction domains. [provided by RefSeq, Dec 2018]
Expression
Broad expression in testis (RPKM 1.9), thyroid (RPKM 1.7) and 23 other tissues See more
Orthologs
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Genomic context

See DZANK1 in Genome Data Viewer
Location:
20p11.23
Exon count:
25
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (18383367..18467180, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18364011..18447674, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ZNF133 antisense RNA 1 Neighboring gene uncharacterized LOC107985418 Neighboring gene long intergenic non-protein coding RNA 851 Neighboring gene glucosaminyl (N-acetyl) transferase 1 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 476 Neighboring gene RNA polymerase III subunit F Neighboring gene microRNA 3192 Neighboring gene ribosomal protein L21 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10600, FLJ30892, DKFZp781J2425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in eye photoreceptor cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
double zinc ribbon and ankyrin repeat-containing protein 1
Names
ankyrin repeat domain 64
ankyrin repeat-containing protein C20orf12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099407.2NP_001092877.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001092877.1

    Status: REVIEWED

    Source sequence(s)
    AK026306, AK055544, AL049646, BC130341, DQ104738
    Consensus CDS
    CCDS46582.1
    UniProtKB/Swiss-Prot
    Q9NVP4
    UniProtKB/TrEMBL
    A1L3Z8
    Related
    ENSP00000262547.5, ENST00000262547.9
    Conserved Domains (5) summary
    cd00204
    Location:618728
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam03174
    Location:1297
    CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
    pfam12773
    Location:339387
    DZR; Double zinc ribbon
    pfam12796
    Location:619707
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:640672
    ANK; ANK repeat [structural motif]
  2. NM_001351683.4NP_001338612.2  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL049646, AL121893
    Conserved Domains (4) summary
    sd00045
    Location:659691
    ANK; ANK repeat [structural motif]
    pfam12773
    Location:358406
    DZR; Double zinc ribbon
    pfam12796
    Location:638726
    Ank_2; Ankyrin repeats (3 copies)
    pfam13287
    Location:32100
    Fn3_assoc; Fn3 associated
  3. NM_001351684.2NP_001338613.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK026306, AK299746, AL049646, AL121893
    Conserved Domains (4) summary
    sd00045
    Location:659691
    ANK; ANK repeat [structural motif]
    pfam12773
    Location:358406
    DZR; Double zinc ribbon
    pfam12796
    Location:638726
    Ank_2; Ankyrin repeats (3 copies)
    pfam13287
    Location:32100
    Fn3_assoc; Fn3 associated
  4. NM_001367611.1NP_001354540.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL049646, AL121893
  5. NM_001367612.1NP_001354541.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL049646, AL121893
  6. NM_001367613.1NP_001354542.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL049646, AL121893
  7. NM_001367614.1NP_001354543.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL049646, AL121893
  8. NM_001367617.1NP_001354546.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL049646, AL121893
  9. NM_001367618.1NP_001354547.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL049646, AL121893
  10. NM_001367619.1NP_001354548.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL049646, AL121893
  11. NM_018152.3NP_060622.2  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL049646, AL121893
    Related
    ENSP00000349774.5, ENST00000357236.8
    Conserved Domains (4) summary
    cd00204
    Location:451561
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12773
    Location:166214
    DZR; Double zinc ribbon
    pfam12796
    Location:452540
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:473505
    ANK; ANK repeat [structural motif]

RNA

  1. NR_160273.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049646, AL121893
  2. NR_160274.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049646, AL121893

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    18383367..18467180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723584.2XP_006723647.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X7

    Conserved Domains (5) summary
    cd00204
    Location:562672
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam03174
    Location:1297
    CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
    pfam12773
    Location:277325
    DZR; Double zinc ribbon
    pfam12796
    Location:563651
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:584616
    ANK; ANK repeat [structural motif]
  2. XM_017027916.2XP_016883405.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X6

  3. XM_017027915.2XP_016883404.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X5

    Conserved Domains (5) summary
    cd00204
    Location:624734
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam03174
    Location:1297
    CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
    pfam12773
    Location:339387
    DZR; Double zinc ribbon
    pfam12796
    Location:625713
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:646678
    ANK; ANK repeat [structural motif]
  4. XM_017027919.2XP_016883408.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X9

    Conserved Domains (4) summary
    cd00204
    Location:510620
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12773
    Location:225273
    DZR; Double zinc ribbon
    pfam12796
    Location:511599
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:532564
    ANK; ANK repeat [structural motif]
  5. XM_017027911.1XP_016883400.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

    Conserved Domains (5) summary
    cd00204
    Location:643753
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam03174
    Location:1297
    CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
    pfam12773
    Location:358406
    DZR; Double zinc ribbon
    pfam12796
    Location:644732
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:665697
    ANK; ANK repeat [structural motif]
  6. XM_017027918.2XP_016883407.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X9

    Conserved Domains (4) summary
    cd00204
    Location:510620
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12773
    Location:225273
    DZR; Double zinc ribbon
    pfam12796
    Location:511599
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:532564
    ANK; ANK repeat [structural motif]
  7. XM_017027910.1XP_016883399.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

    Conserved Domains (5) summary
    cd00204
    Location:643753
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam03174
    Location:1297
    CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
    pfam12773
    Location:358406
    DZR; Double zinc ribbon
    pfam12796
    Location:644732
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:665697
    ANK; ANK repeat [structural motif]
  8. XM_011529272.2XP_011527574.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011527574.1

    Conserved Domains (5) summary
    cd00204
    Location:643753
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam03174
    Location:1297
    CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
    pfam12773
    Location:358406
    DZR; Double zinc ribbon
    pfam12796
    Location:644732
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:665697
    ANK; ANK repeat [structural motif]
  9. XM_011529268.2XP_011527570.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X1

    Conserved Domains (5) summary
    cd00204
    Location:652762
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam03174
    Location:21106
    CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
    pfam12773
    Location:367415
    DZR; Double zinc ribbon
    pfam12796
    Location:653741
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:674706
    ANK; ANK repeat [structural motif]
  10. XM_017027913.2XP_016883402.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X4

  11. XM_017027912.2XP_016883401.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X3

  12. XM_011529271.3XP_011527573.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011527573.1

    Conserved Domains (5) summary
    cd00204
    Location:643753
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam03174
    Location:1297
    CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
    pfam12773
    Location:358406
    DZR; Double zinc ribbon
    pfam12796
    Location:644732
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:665697
    ANK; ANK repeat [structural motif]
  13. XM_017027920.2XP_016883409.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X10

    UniProtKB/Swiss-Prot
    Q9NVP4
    Conserved Domains (4) summary
    cd00204
    Location:451561
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12773
    Location:166214
    DZR; Double zinc ribbon
    pfam12796
    Location:452540
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:473505
    ANK; ANK repeat [structural motif]
  14. XM_024451934.1XP_024307702.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X8

    Conserved Domains (3) summary
    cd00204
    Location:515625
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:537569
    ANK; ANK repeat [structural motif]
    pfam12773
    Location:230278
    DZR; Double zinc ribbon
  15. XM_017027921.2XP_016883410.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X11

    Related
    ENSP00000328866.6, ENST00000329494.9
  16. XM_011529277.2XP_011527579.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X12

    Conserved Domains (4) summary
    cd00204
    Location:305415
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12773
    Location:2068
    DZR; Double zinc ribbon
    pfam12796
    Location:306394
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:327359
    ANK; ANK repeat [structural motif]

RNA

  1. XR_001754314.2 RNA Sequence

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