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MRPS10 mitochondrial ribosomal protein S10 [ Homo sapiens (human) ]

Gene ID: 55173, updated on 3-Mar-2026
Official Symbol
MRPS10provided by HGNC
Official Full Name
mitochondrial ribosomal protein S10provided by HGNC
Primary source
HGNC:HGNC:14502
See related
Ensembl:ENSG00000048544 MIM:611976; AllianceGenome:HGNC:14502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S10mt; uS10m; MRP-S10; PNAS-122
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 21.1), heart (RPKM 17.6) and 25 other tissues See more
Orthologs
all
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See MRPS10 in Genome Data Viewer
Location:
6p21.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (42206807..42217861, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42035014..42046095, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42174545..42185599, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene GUCA1ANB-GUCA1A readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42146768-42147472 Neighboring gene CRISPRi-validated cis-regulatory element chr6.2919 Neighboring gene guanylate cyclase activator 1A Neighboring gene CRISPRi-validated cis-regulatory element chr6.2920 Neighboring gene guanylate cyclase activator 1B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42183711-42184313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42184314-42184915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24544 Neighboring gene uncharacterized LOC105375061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24545 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:42209608-42210190 Neighboring gene transcriptional regulating factor 1 Neighboring gene uncharacterized LOC124901316 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:42225117-42225844

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. Jia L, et al. Genomics, 2002 Jan. PMID 11827452
  2. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. Koc EC, et al. J Biol Chem, 2000 Oct 20. PMID 10938081
  3. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. Yagi M, et al. Nucleic Acids Res, 2012 Oct. PMID 22904065, Free PMC Article
  4. LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus. Wu Z, et al. EMBO J, 2022 Dec 15. PMID 36398858, Free PMC Article
  5. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10567

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
part_of mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HTP PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
small ribosomal subunit protein uS10m
Names
28S ribosomal protein S10, mitochondrial
mitochondrial 28S ribosomal protein S10
mitochondrial small ribosomal subunit protein uS10m
NP_001423567.1
NP_001425135.1
NP_001425779.1
NP_001425780.1
NP_001425781.1
NP_001425782.1
NP_060611.2
XP_011513027.1
XP_054211750.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001436638.1 → NP_001423567.1  small ribosomal subunit protein uS10m isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL096814
    UniProtKB/TrEMBL
    A0ABB0MVD6
    Related
    ENSP00000520760.1, ENST00000718325.1

  2. NM_001438206.1 → NP_001425135.1  small ribosomal subunit protein uS10m isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL096814
    UniProtKB/TrEMBL
    B4DP77
    Related
    ENSP00000566560.1, ENST00000896501.1

  3. NM_001438850.1 → NP_001425779.1  small ribosomal subunit protein uS10m isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL096814
    Related
    ENSP00000604672.1, ENST00000934613.1

  4. NM_001438851.1 → NP_001425780.1  small ribosomal subunit protein uS10m isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL096814
    UniProtKB/TrEMBL
    B4DP77
    Related
    ENSP00000566561.1, ENST00000896502.1

  5. NM_001438852.1 → NP_001425781.1  small ribosomal subunit protein uS10m isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL096814

  6. NM_001438853.1 → NP_001425782.1  small ribosomal subunit protein uS10m isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL096814

  7. NM_018141.4 → NP_060611.2  small ribosomal subunit protein uS10m isoform 2

    See identical proteins and their annotated locations for NP_060611.2

    Status: REVIEWED

    Source sequence(s)
    AF113220, AI683142, AI754661, AW300686, AW974308, BC012560, BG776014
    Consensus CDS
    CCDS4866.1
    UniProtKB/Swiss-Prot
    B2RE89, P82664, Q9H3E5, Q9NVR3
    Related
    ENSP00000053468.3, ENST00000053468.4
    Conserved Domains (1) summary
    pfam00338
    Location:80 → 173
    Ribosomal_S10; Ribosomal protein S10p/S20e

RNA

  1. NR_199179.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL096814
    Related
    ENST00000718327.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    42206807..42217861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514725.4 → XP_011513027.1  small ribosomal subunit protein uS10m isoform X2

    Related
    ENSP00000566562.1, ENST00000896503.1
    Conserved Domains (1) summary
    pfam00338
    Location:89 → 181
    Ribosomal_S10; Ribosomal protein S10p/S20e

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    42035014..42046095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355775.1 → XP_054211750.1  small ribosomal subunit protein uS10m isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P82664.2 GenPept UniProtKB/Swiss-Prot:P82664

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