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MRPS10 mitochondrial ribosomal protein S10 [ Homo sapiens (human) ]

Gene ID: 55173, updated on 2-Mar-2021

Summary

Official Symbol
MRPS10provided by HGNC
Official Full Name
mitochondrial ribosomal protein S10provided by HGNC
Primary source
HGNC:HGNC:14502
See related
Ensembl:ENSG00000048544 MIM:611976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRP-S10; PNAS-122
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 21.1), heart (RPKM 17.6) and 25 other tissues See more
Orthologs
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Genomic context

See MRPS10 in Genome Data Viewer
Location:
6p21.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (42206801..42217870, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42174545..42185599, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr6.2919 Neighboring gene CRISPRi-validated cis-regulatory element chr6.2920 Neighboring gene uncharacterized LOC105375061 Neighboring gene transcriptional regulating factor 1 Neighboring gene uncharacterized LOC107986596

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10567

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
28S ribosomal protein S10, mitochondrial
Names
S10mt
mitochondrial 28S ribosomal protein S10
mitochondrial small ribosomal subunit protein uS10m
NP_060611.2
XP_005249263.1
XP_011513026.1
XP_011513027.1
XP_016866485.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018141.4NP_060611.2  28S ribosomal protein S10, mitochondrial

    See identical proteins and their annotated locations for NP_060611.2

    Status: REVIEWED

    Source sequence(s)
    AF113220, AI683142, AI754661, AW300686, AW974308, BC012560, BG776014
    Consensus CDS
    CCDS4866.1
    UniProtKB/Swiss-Prot
    P82664
    UniProtKB/TrEMBL
    A0A024RD03
    Related
    ENSP00000053468.3, ENST00000053468.4
    Conserved Domains (1) summary
    pfam00338
    Location:80172
    Ribosomal_S10; Ribosomal protein S10p/S20e

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    42206801..42217870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010996.1XP_016866485.1  28S ribosomal protein S10, mitochondrial isoform X4

    UniProtKB/TrEMBL
    B4DP77
    Conserved Domains (1) summary
    pfam00338
    Location:39131
    Ribosomal_S10; Ribosomal protein S10p/S20e
  2. XM_011514725.3XP_011513027.1  28S ribosomal protein S10, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam00338
    Location:89181
    Ribosomal_S10; Ribosomal protein S10p/S20e
  3. XM_011514724.3XP_011513026.1  28S ribosomal protein S10, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam00338
    Location:90182
    Ribosomal_S10; Ribosomal protein S10p/S20e
  4. XM_005249206.3XP_005249263.1  28S ribosomal protein S10, mitochondrial isoform X3

    Conserved Domains (1) summary
    pfam00338
    Location:79171
    Ribosomal_S10; Ribosomal protein S10p/S20e
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