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WRAP53 WD repeat containing antisense to TP53 [ Homo sapiens (human) ]

Gene ID: 55135, updated on 2-Nov-2024

Summary

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Official Symbol
WRAP53provided by HGNC
Official Full Name
WD repeat containing antisense to TP53provided by HGNC
Primary source
HGNC:HGNC:25522
See related
Ensembl:ENSG00000141499 MIM:612661; AllianceGenome:HGNC:25522
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DKCB3; TCAB1; WDR79
Summary
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in lymph node (RPKM 2.8), testis (RPKM 2.5) and 25 other tissues See more
Orthologs
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Genomic context

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See WRAP53 in Genome Data Viewer
Location:
17p13.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7686071..7703502)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7590175..7607622)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7589389..7606820)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11640 Neighboring gene sex hormone binding globulin Neighboring gene ReSE screen-validated silencer GRCh37_chr17:7551198-7551407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7552896-7553396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7553397-7553897 Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7554172-7554814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7558514-7559332 Neighboring gene ATPase Na+/K+ transporting subunit beta 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7571230-7572027 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7580287-7580898 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7580899-7581510 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7581511-7582121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11641 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:7589699-7590898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11643 Neighboring gene tumor protein p53 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr17:7606219-7607112 and GRCh37_chr17:7607113-7608004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7608898-7609789 Neighboring gene ephrin B3 Neighboring gene dynein axonemal heavy chain 2 Neighboring gene ribosomal protein L29 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms. Bug M, et al. Oncogene, 2011 Aug 18. PMID 21441950
  2. Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome. Bergstrand S, et al. Cell Death Dis, 2020 Apr 17. PMID 32303682, Free PMC Article
  3. TCAB1: driving telomerase to Cajal bodies. Venteicher AS, et al. Cell Cycle, 2009 May 1. PMID 19342896
  4. Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke. Sánchez-Morán I, et al. Sci Adv, 2020 Oct. PMID 33028529, Free PMC Article
  5. Regulatory effects of WRAP53 on radiosensitivity of laryngeal squamous cell carcinoma cells. Qiu H, et al. Asian Pac J Cancer Prev, 2015. PMID 25854392

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly.
    Title: TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly.
  2. Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors.
    Title: Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors.
  3. Next-generation sequencing errors due to genetic variation in WRAP53 encoding TCAB1 on chromosome 17.
    Title: Next-generation sequencing errors due to genetic variation in WRAP53 encoding TCAB1 on chromosome 17.
  4. [Effect of WRAP53 beta Targeted Co-Inhibitory Pathways Based on Comprehensive Bioinformatics Analysis in Treating Squamous Cell Carcinoma of the Head and Neck].
    Title: [Effect of WRAP53 β Targeted Co-Inhibitory Pathways Based on Comprehensive Bioinformatics Analysis in Treating Squamous Cell Carcinoma of the Head and Neck].
  5. Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke.
    Title: Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke.
  6. Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome.
    Title: Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome.
  7. analyze a haplotype comprising four SNPs, including rs1042522, rs17878362, rs2287499, and rs2287498, which are located at 5' regions of the TP53 and WRAP53 genes as molecular prognostic and predictive biomarkers for breast cancer.
    Title: Haplotype and linkage disequilibrium of TP53-WRAP53 locus in Iranian-Azeri women with breast cancer.
  8. These findings reveal that WDR79 is a novel UHRF1 regulator by maintaining UHRF1 stability.
    Title: WDR79 mediates the proliferation of non-small cell lung cancer cells by regulating the stability of UHRF1.
  9. we suggest that TDP-43 and WDR79 have separate roles in determining Cajal bodies (CBs) localization of subsets of C/D and H/ACA scaRNAs.
    Title: TDP-43 regulates site-specific 2'-O-methylation of U1 and U2 snRNAs via controlling the Cajal body localization of a subset of C/D scaRNAs.
  10. Data show that up-regulated expression of telomerase Cajal body protein 1 (TCAB1), induced by Epstein-Barr virus (EBV) in the development of nasopharyngeal carcinoma (NPC), is involved in stimulating telomerase activity and regulating the DNA damage response.
    Title: Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10385

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein carrier chaperone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables telomerase RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables telomerase RNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Cajal body organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Cajal body organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of double-strand break repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of establishment of protein localization to telomere IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in scaRNA localization to Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in scaRNA localization to Cajal body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomerase RNA localization to Cajal body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere formation via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of telomere maintenance via telomerase TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Cajal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Cajal body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 
part_of telomerase holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
telomerase Cajal body protein 1
Names
WD repeat-containing protein 79
WD repeat-containing protein WRAP53
WD40 protein Wrap53
WD40 repeat-containing protein antisense to TP53
WD40 repeat-containing protein encoding RNA antisense to p53
WRAP53beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028245.1 RefSeqGene

    Range
    5001..22432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_375

mRNA and Protein(s)

  1. NM_001143990.2 → NP_001137462.1  telomerase Cajal body protein 1

    See identical proteins and their annotated locations for NP_001137462.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as WRAP53gamma) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    DQ431241
    Consensus CDS
    CCDS11119.1
    UniProtKB/Swiss-Prot
    B3KPR9, D3DTQ4, Q08ET9, Q9BUR4, Q9NW09
    UniProtKB/TrEMBL
    E9PMG4
    Related
    ENSP00000397219.2, ENST00000431639.6
    Conserved Domains (2) summary
    sd00039
    Location:175 → 223
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:175 → 480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001143991.2 → NP_001137463.1  telomerase Cajal body protein 1

    See identical proteins and their annotated locations for NP_001137463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as WRAP53alpha) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC087388, AY766322
    Consensus CDS
    CCDS11119.1
    UniProtKB/Swiss-Prot
    B3KPR9, D3DTQ4, Q08ET9, Q9BUR4, Q9NW09
    UniProtKB/TrEMBL
    E9PMG4
    Related
    ENSP00000411061.2, ENST00000457584.6
    Conserved Domains (2) summary
    sd00039
    Location:175 → 223
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:175 → 480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001143992.2 → NP_001137464.1  telomerase Cajal body protein 1

    See identical proteins and their annotated locations for NP_001137464.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as WRAP53beta) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    DQ431240
    Consensus CDS
    CCDS11119.1
    UniProtKB/Swiss-Prot
    B3KPR9, D3DTQ4, Q08ET9, Q9BUR4, Q9NW09
    UniProtKB/TrEMBL
    E9PMG4
    Related
    ENSP00000379727.3, ENST00000396463.7
    Conserved Domains (2) summary
    sd00039
    Location:175 → 223
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:175 → 480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_018081.2 → NP_060551.2  telomerase Cajal body protein 1

    See identical proteins and their annotated locations for NP_060551.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK225411, DQ431240
    Consensus CDS
    CCDS11119.1
    UniProtKB/Swiss-Prot
    B3KPR9, D3DTQ4, Q08ET9, Q9BUR4, Q9NW09
    UniProtKB/TrEMBL
    E9PMG4
    Related
    ENSP00000324203.5, ENST00000316024.9
    Conserved Domains (2) summary
    sd00039
    Location:175 → 223
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:175 → 480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7686071..7703502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7590175..7607622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BUR4.1 GenPept UniProtKB/Swiss-Prot:Q9BUR4

Gene LinkOut

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