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WRAP53 WD repeat containing antisense to TP53 [ Homo sapiens (human) ]

Gene ID: 55135, updated on 7-Oct-2018

Summary

Official Symbol
WRAP53provided by HGNC
Official Full Name
WD repeat containing antisense to TP53provided by HGNC
Primary source
HGNC:HGNC:25522
See related
Ensembl:ENSG00000141499 MIM:612661; Vega:OTTHUMG00000134323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DKCB3; TCAB1; WDR79
Summary
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in lymph node (RPKM 2.8), testis (RPKM 2.5) and 25 other tissues See more
Orthologs

Genomic context

See WRAP53 in Genome Data Viewer
Location:
17p13.1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (7686071..7703502)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7589389..7606820)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sex hormone binding globulin Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene ATPase Na+/K+ transporting subunit beta 2 Neighboring gene tumor protein p53 Neighboring gene ephrin B3 Neighboring gene dynein axonemal heavy chain 2 Neighboring gene ribosomal protein L29 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem (from REACTOME)
    Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystemTRiC has broad recognition specificities, but in the cell it interacts with only a defined set of substrates (Yam et al. 2008). Many of its substrates that are targeted during biosynthesis are conse...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
    Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
  • Chromosome Maintenance, organism-specific biosystem (from REACTOME)
    Chromosome Maintenance, organism-specific biosystemChromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells. Aspects of telomere maintenance and nucleosome assembly are covered here.
  • Extension of Telomeres, organism-specific biosystem (from REACTOME)
    Extension of Telomeres, organism-specific biosystemTelomerase acts as reverse transcriptase in the elongation of telomeres (Smogorzewska and de Lange 2004).
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Protein folding, organism-specific biosystem (from REACTOME)
    Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
  • Telomere Extension By Telomerase, organism-specific biosystem (from REACTOME)
    Telomere Extension By Telomerase, organism-specific biosystemHumans, like most eukaryotic organisms, add direct repeats to the telomere using a specialized DNA polymerase called telomerase. Telomerase is a ribonucleoprotein (RNP) complex minimally composed of...
  • Telomere Maintenance, organism-specific biosystem (from REACTOME)
    Telomere Maintenance, organism-specific biosystemTelomeres are protein-DNA complexes at the ends of linear chromosomes that are important for genome stability. Telomeric DNA in humans, as in many eukaryotic organisms, consists of tandem repeats (B...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10385

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
telomerase RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
telomerase RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Cajal body organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
RNA folding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of double-strand break repair IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of establishment of protein localization to telomere IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to Cajal body TAS
Traceable Author Statement
more info
PubMed 
scaRNA localization to Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
scaRNA localization to Cajal body IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomerase RNA localization to Cajal body HMP PubMed 
telomerase RNA localization to Cajal body IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere formation via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
PubMed 
telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere maintenance via telomerase TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
Cajal body IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 
telomerase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
telomerase Cajal body protein 1
Names
WD repeat-containing protein 79
WD repeat-containing protein WRAP53
WD40 protein Wrap53
WD40 repeat-containing protein antisense to TP53
WD40 repeat-containing protein encoding RNA antisense to p53
WRAP53beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028245.1 RefSeqGene

    Range
    5001..22432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_375

mRNA and Protein(s)

  1. NM_001143990.1NP_001137462.1  telomerase Cajal body protein 1

    See identical proteins and their annotated locations for NP_001137462.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as WRAP53gamma) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    DQ431241
    Consensus CDS
    CCDS11119.1
    UniProtKB/Swiss-Prot
    Q9BUR4
    Related
    ENSP00000397219.2, OTTHUMP00000233829, ENST00000431639.6, OTTHUMT00000390883
    Conserved Domains (2) summary
    sd00039
    Location:175223
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:175480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001143991.1NP_001137463.1  telomerase Cajal body protein 1

    See identical proteins and their annotated locations for NP_001137463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as WRAP53alpha) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AY766322
    Consensus CDS
    CCDS11119.1
    UniProtKB/Swiss-Prot
    Q9BUR4
    Related
    ENSP00000411061.2, OTTHUMP00000233830, ENST00000457584.6, OTTHUMT00000390884
    Conserved Domains (2) summary
    sd00039
    Location:175223
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:175480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001143992.1NP_001137464.1  telomerase Cajal body protein 1

    See identical proteins and their annotated locations for NP_001137464.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as WRAP53beta) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    DQ431240
    Consensus CDS
    CCDS11119.1
    UniProtKB/Swiss-Prot
    Q9BUR4
    Related
    ENSP00000379727.2, OTTHUMP00000166047, ENST00000396463.6, OTTHUMT00000259386
    Conserved Domains (2) summary
    sd00039
    Location:175223
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:175480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_018081.2NP_060551.2  telomerase Cajal body protein 1

    See identical proteins and their annotated locations for NP_060551.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK225411, DQ431240
    Consensus CDS
    CCDS11119.1
    UniProtKB/Swiss-Prot
    Q9BUR4
    Related
    ENSP00000324203.5, OTTHUMP00000166046, ENST00000316024.9, OTTHUMT00000259385
    Conserved Domains (2) summary
    sd00039
    Location:175223
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:175480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    7686071..7703502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450825.1XP_024306593.1  telomerase Cajal body protein 1 isoform X3

    Related
    ENSP00000432991.1, ENST00000498311.5
  2. XM_024450824.1XP_024306592.1  telomerase Cajal body protein 1 isoform X2

    Conserved Domains (2) summary
    COG2319
    Location:54216
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:65101
    7WD40; WD40 repeat [structural motif]
  3. XM_011523952.2XP_011522254.1  telomerase Cajal body protein 1 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:27267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:68110
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:27267
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_001752551.2 RNA Sequence

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