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Wrap53 WD repeat containing, antisense to Trp53 [ Mus musculus (house mouse) ]

Gene ID: 216853, updated on 19-Nov-2022

Summary

Official Symbol
Wrap53provided by MGI
Official Full Name
WD repeat containing, antisense to Trp53provided by MGI
Primary source
MGI:MGI:2384933
See related
Ensembl:ENSMUSG00000041346 AllianceGenome:MGI:2384933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr79
Summary
Predicted to enable several functions, including chaperone binding activity; telomerase RNA binding activity; and ubiquitin protein ligase binding activity. Involved in positive regulation of telomerase activity. Predicted to be located in cytosol; nuclear body; and site of double-strand break. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in Cajal body. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 3; colorectal cancer; head and neck squamous cell carcinoma; lung non-small cell carcinoma; and ovarian cancer. Orthologous to human WRAP53 (WD repeat containing antisense to TP53). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 8.1), large intestine adult (RPKM 6.4) and 28 other tissues See more
Orthologs
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Genomic context

See Wrap53 in Genome Data Viewer
Location:
11; 11 B3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69452580..69471076, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69561754..69580250, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 2 Neighboring gene ephrin B3 Neighboring gene ribosomal protein S27, pseudogene 2 Neighboring gene transformation related protein 53 Neighboring gene ATPase, Na+/K+ transporting, beta 2 polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC28622

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Cajal body organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Cajal body organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA folding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of establishment of protein localization to telomere ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to Cajal body ISO
Inferred from Sequence Orthology
more info
 
involved_in scaRNA localization to Cajal body ISO
Inferred from Sequence Orthology
more info
 
involved_in telomerase RNA localization to Cajal body ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere formation via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Cajal body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
telomerase Cajal body protein 1
Names
WD repeat containing, antisense to TP53
WD repeat domain 79
WD repeat-containing protein 79
WD repeat-containing protein WRAP53
WD40 repeat-containing protein antisense to TP53 gene homolog
WD40 repeat-containing protein encoded by RNA antisense to p53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364769.1NP_001351698.1  telomerase Cajal body protein 1

    Status: VALIDATED

    Source sequence(s)
    AL731687
    Consensus CDS
    CCDS24897.1
    UniProtKB/Swiss-Prot
    Q8VC51
    Conserved Domains (2) summary
    sd00039
    Location:159204
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:159465
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_144824.3NP_659073.1  telomerase Cajal body protein 1

    See identical proteins and their annotated locations for NP_659073.1

    Status: VALIDATED

    Source sequence(s)
    AL731687
    Consensus CDS
    CCDS24897.1
    UniProtKB/Swiss-Prot
    Q8VC51
    Related
    ENSMUSP00000047825.6, ENSMUST00000048139.12
    Conserved Domains (2) summary
    sd00039
    Location:159204
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:159465
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69452580..69471076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532899.5XP_006532962.1  telomerase Cajal body protein 1 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:156203
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:134254
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006532900.5XP_006532963.1  telomerase Cajal body protein 1 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:156203
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:134254
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_388402.5 RNA Sequence