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WDR70 WD repeat domain 70 [ Homo sapiens (human) ]

Gene ID: 55100, updated on 4-Sep-2021

Summary

Official Symbol
WDR70provided by HGNC
Official Full Name
WD repeat domain 70provided by HGNC
Primary source
HGNC:HGNC:25495
See related
Ensembl:ENSG00000082068 MIM:617233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in endometrium (RPKM 8.3), testis (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

See WDR70 in Genome Data Viewer
Location:
5p13.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (37379318..37753435)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (37379420..37753537)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ciliogenesis and planar polarity effector 1 Neighboring gene uncharacterized LOC105374727 Neighboring gene nucleoporin 155 Neighboring gene RNA, U7 small nuclear 75 pseudogene Neighboring gene potassium channel tetramerization domain containing 9 pseudogene 5 Neighboring gene RNA, U6 small nuclear 1190, pseudogene Neighboring gene Sharpr-MPRA regulatory region 6618 Neighboring gene RNA, U6 small nuclear 484, pseudogene Neighboring gene GDNF antisense RNA 1 Neighboring gene glial cell derived neurotrophic factor Neighboring gene long intergenic non-protein coding RNA 2117

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA double-strand break processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of histone H2B conserved C-terminal lysine ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001345998.2NP_001332927.1  WD repeat-containing protein 70 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC025469, AC093269, AC117532
  2. NM_001345999.2NP_001332928.1  WD repeat-containing protein 70 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC025469, AC093269, AC117532
  3. NM_018034.4NP_060504.1  WD repeat-containing protein 70 isoform 1

    See identical proteins and their annotated locations for NP_060504.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC093269, BC009648
    Consensus CDS
    CCDS34147.1
    UniProtKB/Swiss-Prot
    Q9NW82
    Related
    ENSP00000265107.4, ENST00000265107.9
    Conserved Domains (2) summary
    sd00039
    Location:185227
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:177498
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    37379318..37753435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514061.2XP_011512363.1  WD repeat-containing protein 70 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:38250
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:4482
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:38256
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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