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Conserved domains on  [gi|767934477|ref|XP_011512363|]
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WD repeat-containing protein 70 isoform X2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-256 4.33e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 4.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  38 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKQKsvfkprTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQI 116
Cdd:cd00200   90 TGHTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477 117 WD-RNLTVHPKFHykqAHDSgtDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFN--KPLFSASGlptmfPMTDCCFSPDD 193
Cdd:cd00200  162 WDlRTGKCVATLT---GHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKclGTLRGHEN-----GVNSVAFSPDG 231

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767934477 194 KLIVTGTsiqrgcGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVY 256
Cdd:cd00200  232 YLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-256 4.33e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 4.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  38 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKQKsvfkprTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQI 116
Cdd:cd00200   90 TGHTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477 117 WD-RNLTVHPKFHykqAHDSgtDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFN--KPLFSASGlptmfPMTDCCFSPDD 193
Cdd:cd00200  162 WDlRTGKCVATLT---GHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKclGTLRGHEN-----GVNSVAFSPDG 231

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767934477 194 KLIVTGTsiqrgcGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVY 256
Cdd:cd00200  232 YLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
38-256 6.05e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 6.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  38 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQI 116
Cdd:COG2319  117 TGHTGAVRSVAFSPD--GKTLaSGSADGTVRLWDLATGKL------LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477 117 WD-------RNLTVHPKFHYkqahdsgtdtsCVTFSYDGNVLASRGGDDSLKLWDIRQfNKPLFSASGLPtmFPMTDCCF 189
Cdd:COG2319  189 WDlatgkllRTLTGHTGAVR-----------SVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHS--GSVRSVAF 254

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767934477 190 SPDDKLIVTGTsiqrgcGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVY 256
Cdd:COG2319  255 SPDGRLLASGS------ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
PTZ00420 PTZ00420
coronin; Provisional
 38-176 3.20e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 58.81  E-value: 3.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  38 KGHTAMLHTGSWHPKikGEFMTCSN--DATVRTWEVENPKKQKSVFKPRTMQGKKvipttctYSRDGNLIAAACQNGSIQ 115
Cdd:PTZ00420 122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLK-------WNIKGNLLSGTCVGKHMH 192

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767934477 116 IWD-RNLTVHPKFHykqAHDSGTDTSCV---TFSYDGNVLASRGGDDS----LKLWDIRQFNKPLFSAS 176
Cdd:PTZ00420 193 IIDpRKQEIASSFH---IHDGGKNTKNIwidGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 84-118 7.33e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 7.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767934477    84 RTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWD 118
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-256 4.33e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 4.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  38 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKQKsvfkprTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQI 116
Cdd:cd00200   90 TGHTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477 117 WD-RNLTVHPKFHykqAHDSgtDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFN--KPLFSASGlptmfPMTDCCFSPDD 193
Cdd:cd00200  162 WDlRTGKCVATLT---GHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKclGTLRGHEN-----GVNSVAFSPDG 231

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767934477 194 KLIVTGTsiqrgcGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVY 256
Cdd:cd00200  232 YLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-256 3.19e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 3.19e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  38 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKQksvfkpRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQI 116
Cdd:cd00200    6 KGHTGGVTCVAFSPD--GKLLaTGSGDGTIKVWDLETGELL------RTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477 117 WDRNlTVHPKFHYKQaHDSgtDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFnKPLFSASGLPTmfPMTDCCFSPDDKLI 196
Cdd:cd00200   78 WDLE-TGECVRTLTG-HTS--YVSSVAFSPDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTD--WVNSVAFSPDGTFV 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477 197 VTgtsiqrGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVY 256
Cdd:cd00200  151 AS------SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
38-256 6.05e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 6.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  38 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQI 116
Cdd:COG2319  117 TGHTGAVRSVAFSPD--GKTLaSGSADGTVRLWDLATGKL------LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477 117 WD-------RNLTVHPKFHYkqahdsgtdtsCVTFSYDGNVLASRGGDDSLKLWDIRQfNKPLFSASGLPtmFPMTDCCF 189
Cdd:COG2319  189 WDlatgkllRTLTGHTGAVR-----------SVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHS--GSVRSVAF 254

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767934477 190 SPDDKLIVTGTsiqrgcGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVY 256
Cdd:COG2319  255 SPDGRLLASGS------ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
38-256 3.73e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 3.73e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  38 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQI 116
Cdd:COG2319  201 TGHTGAVRSVAFSPD--GKLLaSGSADGTVRLWDLATGKL------LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477 117 WDRNltvHPKFHYKQAHDSGTDTScVTFSYDGNVLASRGGDDSLKLWDIRQfNKPLFSASGLPTMFpmTDCCFSPDDKLI 196
Cdd:COG2319  273 WDLA---TGELLRTLTGHSGGVNS-VAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAV--RSVAFSPDGKTL 345

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477 197 VTGTSiqrgcgSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVY 256
Cdd:COG2319  346 ASGSD------DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
3-199 3.23e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 3.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477   3 LVVSGSS--QAKVIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKqks 79
Cdd:COG2319  218 LLASGSAdgTVRLWDLATGKLL------------RTLTGHSGSVRSVAFSPD--GRLLaSGSADGTVRLWDLATGEL--- 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  80 vfkPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHykQAHDSgtDTSCVTFSYDGNVLASRGGDDS 159
Cdd:COG2319  281 ---LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL--TGHTG--AVRSVAFSPDGKTLASGSDDGT 353

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767934477 160 LKLWDIRQfNKPLFSASGLPTmfPMTDCCFSPDDKLIVTG 199
Cdd:COG2319  354 VRLWDLAT-GELLRTLTGHTG--AVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
39-256 1.61e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 1.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  39 GHTAMLHTGSWHPKIKGeFMTCSNDATVRTWEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWD 118
Cdd:COG2319   76 GHTAAVLSVAFSPDGRL-LASASADGTVRLWDLATGLL------LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477 119 -------RNLTVHPKfhykqahdsgtDTSCVTFSYDGNVLASRGGDDSLKLWDIRQfNKPLFSASGLPTMFpmTDCCFSP 191
Cdd:COG2319  149 latgkllRTLTGHSG-----------AVTSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAV--RSVAFSP 214

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767934477 192 DDKLIVTGTsiqrgcGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVY 256
Cdd:COG2319  215 DGKLLASGS------ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-164 1.22e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 1.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477   3 LVVSGSS--QAKVIDrdgFEVMECIKgdqyivdmaNTKGHTAMLHTGSWHPKiKGEFMTCSNDATVRTWEVENPKKQKsv 80
Cdd:cd00200  149 FVASSSQdgTIKLWD---LRTGKCVA---------TLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLG-- 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  81 fkprTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWD-RNLTVHPKFhykQAHDSGTdtSCVTFSYDGNVLASRGGDDS 159
Cdd:cd00200  214 ----TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDlRTGECVQTL---SGHTNSV--TSLAWSPDGKRLASGSADGT 284


                 ....*
gi 767934477 160 LKLWD 164
Cdd:cd00200  285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
3-166 3.56e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 3.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477   3 LVVSGSS--QAKVIDRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVRTWEVENPKKqks 79
Cdd:COG2319  260 LLASGSAdgTVRLWDLATGELLRTLTG------------HSGGVNSVAFSPD--GKLLaSGSDDGTVRLWDLATGKL--- 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  80 vfkPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWDrnLTVHPKFHYKQAHDSGTdtSCVTFSYDGNVLASRGGDDS 159
Cdd:COG2319  323 ---LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD--LATGELLRTLTGHTGAV--TSVAFSPDGRTLASGSADGT 395


                 ....*..
gi 767934477 160 LKLWDIR 166
Cdd:COG2319  396 VRLWDLA 402
PTZ00420 PTZ00420
coronin; Provisional
 38-176 3.20e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 58.81  E-value: 3.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  38 KGHTAMLHTGSWHPKikGEFMTCSN--DATVRTWEVENPKKQKSVFKPRTMQGKKvipttctYSRDGNLIAAACQNGSIQ 115
Cdd:PTZ00420 122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLK-------WNIKGNLLSGTCVGKHMH 192

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767934477 116 IWD-RNLTVHPKFHykqAHDSGTDTSCV---TFSYDGNVLASRGGDDS----LKLWDIRQFNKPLFSAS 176
Cdd:PTZ00420 193 IIDpRKQEIASSFH---IHDGGKNTKNIwidGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
PTZ00421 PTZ00421
coronin; Provisional
 38-217 2.41e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477  38 KGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENpKKQKSVFKPRTMQGkkvipTTCTYSRDGNLIAAACQNGSIQIW 117
Cdd:PTZ00421 122 QGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVIKCHSDQI-----TSLEWNLDGSLLCTTSKDKKLNII 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934477 118 D-RNLTVhpkFHYKQAHDSGTDTSCVtFSYDGNVLASRGGDDS----LKLWDIRQFNKPL-------FSASGLPTmfpmt 185
Cdd:PTZ00421 196 DpRDGTI---VSSVEAHASAKSQRCL-WAKRKDLIITLGCSKSqqrqIMLWDTRKMASPYstvdldqSSALFIPF----- 266

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767934477 186 dccFSPDDKLIVTGTSiqrgcGSGKLVFFERR 217
Cdd:PTZ00421 267 ---FDEDTNLLYIGSK-----GEGNIRCFELM 290
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 84-118 7.33e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 7.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767934477    84 RTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWD 118
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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