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MED9 mediator complex subunit 9 [ Homo sapiens (human) ]

Gene ID: 55090, updated on 1-Jun-2020

Summary

Official Symbol
MED9provided by HGNC
Official Full Name
mediator complex subunit 9provided by HGNC
Primary source
HGNC:HGNC:25487
See related
Ensembl:ENSG00000141026 MIM:609878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MED25
Summary
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 9.0), brain (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See MED9 in Genome Data Viewer
Location:
17p11.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (17477000..17493221)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17380300..17396534)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ligand of numb-protein X 1, E3 ubiquitin protein ligase pseudogene Neighboring gene tRNA splicing endonuclease subunit 15 pseudogene 1 Neighboring gene ras related dexamethasone induced 1 Neighboring gene phosphatidylethanolamine N-methyltransferase Neighboring gene VISTA enhancer hs1917

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10193, MGC138234

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 9
Names
mediator of RNA polymerase II transcription, subunit 9 homolog
mediator subunit 25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018019.3NP_060489.1  mediator of RNA polymerase II transcription subunit 9

    See identical proteins and their annotated locations for NP_060489.1

    Status: REVIEWED

    Source sequence(s)
    AC073621
    Consensus CDS
    CCDS11184.1
    UniProtKB/Swiss-Prot
    Q9NWA0
    Related
    ENSP00000268711.3, ENST00000268711.4
    Conserved Domains (1) summary
    pfam07544
    Location:64139
    Med9; RNA polymerase II transcription mediator complex subunit 9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    17477000..17493221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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