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ARGLU1 arginine and glutamate rich 1 [ Homo sapiens (human) ]

Gene ID: 55082, updated on 17-Jun-2024


Official Symbol
ARGLU1provided by HGNC
Official Full Name
arginine and glutamate rich 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000134884 MIM:614046; AllianceGenome:HGNC:25482
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Enables cadherin binding activity. Located in cytosol; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in lung (RPKM 83.2), spleen (RPKM 81.9) and 25 other tissues See more
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Genomic context

See ARGLU1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (106541673..106568137, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (105762093..105788553, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (107194021..107220485, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:107124121-107125320 Neighboring gene uncharacterized LOC105370346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:107125598-107126285 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:107131600-107132799 Neighboring gene uncharacterized LOC124903247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:107144828-107145328 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:107145476-107146675 Neighboring gene ephrin B2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:107178953-107179606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7982 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:107219841-107220751 Neighboring gene ARGLU1 divergent transcript Neighboring gene long intergenic non-protein coding RNA 443 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 5

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of arginine and glutamate rich 1 (ARGLU1; FLJ 10154) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Clone Names

  • FLJ10154, DKFZp686O08106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
located_in mitochondrion IDA
Inferred from Direct Assay
more info
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
located_in nucleoplasm IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
arginine and glutamate-rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018011.4NP_060481.3  arginine and glutamate-rich protein 1

    See identical proteins and their annotated locations for NP_060481.3

    Status: VALIDATED

    Source sequence(s)
    AA445997, AI623424, AL442127, BC050434, DB482545
    Consensus CDS
    B4E0Y3, Q5T257, Q6IQ34, Q9NWB6
    ENSP00000383059.3, ENST00000400198.8
    Conserved Domains (1) summary
    ARGLU; Arginine and glutamate-rich 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    106541673..106568137 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060937.1 Alternate T2T-CHM13v2.0

    105762093..105788553 complement
    GenBank, FASTA, Sequence Viewer (Graphics)