enpp4 ectonucleotide pyrophosphatase/phosphodiesterase 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: enpp4provided by ZNC
Official Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-444
See related: Ensembl:ENSDARG00000006877 AllianceGenome:ZFIN:ZDB-GENE-050417-444
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: E-NPP 4; zgc:113299
Summary: Predicted to enable bis(5'-adenosyl)-triphosphatase activity and metal ion binding activity. Predicted to act upstream of or within blood coagulation and positive regulation of blood coagulation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human ENPP4 (ectonucleotide pyrophosphatase/phosphodiesterase 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (5599014..5610514, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (5441918..5453418, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables bis(5'-adenosyl)-triphosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bis(5'-adenosyl)-triphosphatase enpp4

Names: AP3A hydrolase; AP3Aase; E-NPP4; NPP-4; ectonucleotide pyrophosphatase/phosphodiesterase family member 4

NP_001017887.1

EC 3.6.1.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017887.1 → NP_001017887.1 bis(5'-adenosyl)-triphosphatase enpp4 precursor

See identical proteins and their annotated locations for NP_001017887.1

Status: PROVISIONAL

Source sequence(s)

BC093443

UniProtKB/Swiss-Prot

Q566N0

Related

ENSDARP00000004660.5, ENSDART00000004043.6

Conserved Domains (2) summary

pfam01663
Location:34 → 343

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cd16018
Location:32 → 383

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin