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ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 [ Homo sapiens (human) ]

Gene ID: 22875, updated on 13-Mar-2020

Summary

Official Symbol
ENPP4provided by HGNC
Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 4provided by HGNC
Primary source
HGNC:HGNC:3359
See related
Ensembl:ENSG00000001561 MIM:617000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPP4
Expression
Ubiquitous expression in bone marrow (RPKM 15.7), brain (RPKM 14.1) and 24 other tissues See more
Orthologs

Genomic context

See ENPP4 in Genome Data Viewer
Location:
6p21.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (46129989..46146688)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46097701..46114436)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375078 Neighboring gene chloride intracellular channel 5 Neighboring gene RNA, U6 small nuclear 754, pseudogene Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Neighboring gene actin gamma 1 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0879

Gene Ontology Provided by GOA

Function Evidence Code Pubs
bis(5'-adenosyl)-triphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
purine ribonucleoside catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
bis(5'-adenosyl)-triphosphatase ENPP4
Names
AP3A hydrolase
AP3Aase
E-NPP 4
NPP-4
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function)
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ectonucleotide pyrophosphatase/phosphodiesterase family member 4
NP_055751.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014936.5NP_055751.1  bis(5'-adenosyl)-triphosphatase ENPP4 precursor

    See identical proteins and their annotated locations for NP_055751.1

    Status: VALIDATED

    Source sequence(s)
    AB020686, CA433087, DA261977
    Consensus CDS
    CCDS34468.1
    UniProtKB/Swiss-Prot
    Q9Y6X5
    Related
    ENSP00000318066.3, ENST00000321037.5
    Conserved Domains (2) summary
    pfam01663
    Location:28339
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:26379
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    46129989..46146688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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