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MRPL20 mitochondrial ribosomal protein L20 [ Homo sapiens (human) ]

Gene ID: 55052, updated on 21-Dec-2019


Official Symbol
MRPL20provided by HGNC
Official Full Name
mitochondrial ribosomal protein L20provided by HGNC
Primary source
See related
Ensembl:ENSG00000242485 MIM:611833
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L20mt; MRP-L20
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Ubiquitous expression in kidney (RPKM 36.6), fat (RPKM 35.3) and 25 other tissues See more

Genomic context

See MRPL20 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (1401909..1407293, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1337276..1342693, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 8 Neighboring gene cyclin L2 Neighboring gene MRPL20 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 657, pseudogene Neighboring gene uncharacterized LOC107984868 Neighboring gene uncharacterized LOC105378585 Neighboring gene ankyrin repeat domain 65

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC4779, MGC74465

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
rRNA binding IEA
Inferred from Electronic Annotation
more info
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
mitochondrial translational termination TAS
Traceable Author Statement
more info
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
mitochondrial ribosome IDA
Inferred from Direct Assay
more info
mitochondrion IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
39S ribosomal protein L20, mitochondrial
mitochondrial large ribosomal subunit protein bL20m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318485.2NP_001305414.1  39S ribosomal protein L20, mitochondrial isoform 2

    Status: REVIEWED

    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus, and is shorter that isoform 1.
    Source sequence(s)
    AA824533, AL391244, BG700526, BM818788, DN990876
    Conserved Domains (1) summary
    Ribosomal_L20; Ribosomal protein L20
  2. NM_017971.4NP_060441.2  39S ribosomal protein L20, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_060441.2

    Status: REVIEWED

    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AW015403, BC009515, BG700526
    Consensus CDS
    ENSP00000341082.7, ENST00000344843.12
    Conserved Domains (1) summary
    Ribosomal_L20; Ribosomal protein L20

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    1401909..1407293 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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