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PPP2R3C protein phosphatase 2 regulatory subunit B''gamma [ Homo sapiens (human) ]

Gene ID: 55012, updated on 21-Dec-2019

Summary

Official Symbol
PPP2R3Cprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit B''gammaprovided by HGNC
Primary source
HGNC:HGNC:17485
See related
Ensembl:ENSG00000092020 MIM:615902
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G4-1; G5pr; GDRM; SPGF36; C14orf10
Summary
This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Broad expression in testis (RPKM 18.2), bone marrow (RPKM 7.6) and 24 other tissues See more
Orthologs

Genomic context

See PPP2R3C in Genome Data Viewer
Location:
14q13.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (35085467..35122662, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (35554678..35591868, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene signal recognition particle 54 Neighboring gene family with sequence similarity 177 member A1 Neighboring gene uncharacterized LOC101927178 Neighboring gene protein only RNase P catalytic subunit Neighboring gene ribosomal protein L23a pseudogene 70 Neighboring gene septin 7 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20644

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
cortical cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of antimicrobial humoral response IEA
Inferred from Electronic Annotation
more info
 
regulation of dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
 
spleen development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
Names
protein phosphatase 2 (formerly 2A), regulatory subunit B''
protein phosphatase 2, regulatory subunit B'', gamma
protein phosphatase subunit G5PR
rhabdomyosarcoma antigen MU-RMS-40.6A
rhabdomyosarcoma antigen Mu-RMS-40.6C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305155.1NP_001292084.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_001292084.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in its 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AA603611, AY157304, BC063438, BI546396
    UniProtKB/Swiss-Prot
    Q969Q6
    Conserved Domains (1) summary
    COG5126
    Location:175303
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. NM_001305156.1NP_001292085.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_001292085.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks an alternate internal exon in its 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AA603611, AK293717, AL121594, BX248043, DA617813
    UniProtKB/Swiss-Prot
    Q969Q6
    Conserved Domains (1) summary
    COG5126
    Location:175303
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  3. NM_017917.3NP_060387.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_060387.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA603611, AY157304, BI546396
    Consensus CDS
    CCDS9654.1
    UniProtKB/Swiss-Prot
    Q969Q6
    Related
    ENSP00000261475.5, ENST00000261475.9

RNA

  1. NR_130972.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA603611, AL121594, BC100021, BX248043, DA617813
    Related
    ENST00000553273.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    35085467..35122662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449638.1XP_024305406.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2

  2. XM_005267782.4XP_005267839.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_005267839.1

    UniProtKB/Swiss-Prot
    Q969Q6
  3. XM_024449639.1XP_024305407.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X4

  4. XM_017021388.2XP_016876877.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X3

RNA

  1. XR_002957558.1 RNA Sequence

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