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PAK1IP1 PAK1 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 55003, updated on 3-May-2020

Summary

Official Symbol
PAK1IP1provided by HGNC
Official Full Name
PAK1 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:20882
See related
Ensembl:ENSG00000111845 MIM:607811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIP1; MAK11; WDR84; hPIP1; bA421M1.5
Expression
Ubiquitous expression in prostate (RPKM 23.6), appendix (RPKM 6.7) and 24 other tissues See more
Orthologs

Genomic context

See PAK1IP1 in Genome Data Viewer
Location:
6p24.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (10690865..10709782)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (10695180..10710015)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374924 Neighboring gene chromosome 6 open reading frame 52 Neighboring gene uncharacterized LOC105374923 Neighboring gene transmembrane protein 14C Neighboring gene transmembrane protein 14B Neighboring gene RNA, 5S ribosomal pseudogene 203

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20624

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
p21-activated protein kinase-interacting protein 1
Names
PAK/PLC-interacting protein 1
WD repeat-containing protein 84

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017906.3NP_060376.2  p21-activated protein kinase-interacting protein 1

    See identical proteins and their annotated locations for NP_060376.2

    Status: VALIDATED

    Source sequence(s)
    AF283303, AL358777, BC010907, BU618231
    Consensus CDS
    CCDS34339.1
    UniProtKB/Swiss-Prot
    Q9NWT1
    UniProtKB/TrEMBL
    A0A0S2Z5C3
    Related
    ENSP00000368887.3, ENST00000379568.4
    Conserved Domains (3) summary
    COG2319
    Location:26277
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:4580
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:41275
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    10690865..10709782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514720.1XP_011513022.1  p21-activated protein kinase-interacting protein 1 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:60300
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:68103
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:64298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_011514721.1XP_011513023.1  p21-activated protein kinase-interacting protein 1 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:59299
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:67102
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:63297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_005249204.2XP_005249261.1  p21-activated protein kinase-interacting protein 1 isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:38278
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:4681
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:42276
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654713.1 Reference GRCh38.p13 PATCHES

    Range
    205856..220666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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