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ADPRS ADP-ribosylserine hydrolase [ Homo sapiens (human) ]

Gene ID: 54936, updated on 9-Oct-2022

Summary

Official Symbol
ADPRSprovided by HGNC
Official Full Name
ADP-ribosylserine hydrolaseprovided by HGNC
Primary source
HGNC:HGNC:21304
See related
Ensembl:ENSG00000116863 MIM:610624; AllianceGenome:HGNC:21304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARH3; ADPRHL2; CONDSIAS
Summary
This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
Expression
Ubiquitous expression in testis (RPKM 14.2), lung (RPKM 13.1) and 25 other tissues See more
Orthologs
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Genomic context

See ADPRS in Genome Data Viewer
Location:
1p34.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (36088892..36093932)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (35951768..35956812)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36554493..36559533)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene magnesium transporter 1 pseudogene Neighboring gene tektin 2 Neighboring gene collagen type VIII alpha 2 chain Neighboring gene trafficking protein particle complex subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20446

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in base-excision repair, gap-filling TAS
Traceable Author Statement
more info
 
involved_in cellular response to superoxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-serine ADP-deribosylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of DNA damage IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylhydrolase ARH3
Names
ADP-ribose glycohydrolase ARH3
ADP-ribosylarginine hydrolase like 2
ADP-ribosylhydrolase 3
ADP-ribosylhydrolase like 2
O-acetyl-ADP-ribose deacetylase ARH3
[Protein ADP-ribosylarginine] hydrolase-like protein 2
[Protein ADP-ribosylserine] hydrolase
poly(ADP-ribose) glycohydrolase ARH3
protein ADP-ribosylarginine hydrolase-like protein 2
NP_060295.1
XP_011539938.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017825.3NP_060295.1  ADP-ribosylhydrolase ARH3

    See identical proteins and their annotated locations for NP_060295.1

    Status: REVIEWED

    Source sequence(s)
    BC014169
    Consensus CDS
    CCDS402.1
    UniProtKB/Swiss-Prot
    Q9BY47, Q9NX46
    Related
    ENSP00000362273.4, ENST00000373178.5
    Conserved Domains (1) summary
    cl00614
    Location:22339
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    36088892..36093932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541636.3XP_011539938.1  ADP-ribosylhydrolase ARH3 isoform X1

    See identical proteins and their annotated locations for XP_011539938.1

    UniProtKB/TrEMBL
    B7ZAN4
    Conserved Domains (1) summary
    pfam03747
    Location:1184
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    35951768..35956812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)