Adprs ADP-ribosylserine hydrolase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adprsprovided by MGI
Official Full Name: ADP-ribosylserine hydrolaseprovided by MGI
Primary source: MGI:MGI:2140364
See related: Ensembl:ENSMUSG00000042558 AllianceGenome:MGI:2140364
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arh3; Adprhl2
Summary: Enables ADP-ribosylserine hydrolase activity and poly(ADP-ribose) glycohydrolase activity. Involved in peptidyl-serine ADP-deribosylation. Acts upstream of or within cellular response to superoxide. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human ADPRS (ADP-ribosylserine hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 51.4), adrenal adult (RPKM 31.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 D2.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (126210144..126215496, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (126316351..126321703, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arh3-deficient mouse showed vulnerability to parthanatos. Arh3-/- fibroblasts demonstrated the failure of normal poly(ADP-ribose) (PAR) degradation in the nucleus and cytoplasm resulted in apoptosis-inducing factor-mediated DNA fragmentation. Data indicate that Arh3 is a PAR-degrading enzyme responsible for the regulation of PAR metabolism under conditions of oxidative stress both in vivo and in vitro.
Title: PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells.
ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose).
Title: ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose).
structural comparison of mouse ADP-ribosylhydrolase 3 with its human orthologue shows a high degree of structural similarity
Title: Structure of mouse ADP-ribosylhydrolase 3 (mARH3).
ARH3 has poly(ADP-ribose) glycohydrolase activity but is structurally unrelated to poly(ADP-ribose) glycohydrolase
Title: Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235026

AU014974 (e-PCR)
- UniSTS:207679

AI836109 (e-PCR)
- UniSTS:179065

Homology

Homologs of the Adprs gene: The Adprs gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, mosquito, and frog.
Orthologs from Annotation Pipeline: 501 organisms have orthologs with human gene Adprs
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP-ribosylserine hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ADP-ribosylserine hydrolase activity	ISO Inferred from Sequence Orthology more info
enables O-acetyl-ADP-ribose deacetylase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(ADP-ribose) glycohydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables poly(ADP-ribose) glycohydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to superoxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to superoxide	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of necroptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine ADP-deribosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine ADP-deribosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylhydrolase ARH3

Names: ADP-ribose glycohydrolase ARH3; ADP-ribosylhydrolase 2; ADP-ribosylhydrolase 3; ADP-ribosylhydrolase like 2; O-acetyl-ADP-ribose deacetylase ARH3; [Protein ADP-ribosylarginine] hydrolase-like protein 2; [Protein ADP-ribosylserine] hydrolase; ecto ADP-ribosylhydrolase; poly(ADP-ribose) glycohydrolase ARH3

NP_598644.1

EC 3.2.1.143

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.