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CMTM6 CKLF like MARVEL transmembrane domain containing 6 [ Homo sapiens (human) ]

Gene ID: 54918, updated on 25-Sep-2022

Summary

Official Symbol
CMTM6provided by HGNC
Official Full Name
CKLF like MARVEL transmembrane domain containing 6provided by HGNC
Primary source
HGNC:HGNC:19177
See related
Ensembl:ENSG00000091317 MIM:607889; AllianceGenome:HGNC:19177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKLFSF6; PRO2219
Summary
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 47.3), thyroid (RPKM 44.1) and 25 other tissues See more
Orthologs
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Genomic context

See CMTM6 in Genome Data Viewer
Location:
3p22.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (32481312..32502852, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (32478266..32499821, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32522804..32544344, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CKLF like MARVEL transmembrane domain containing 7 Neighboring gene Sharpr-MPRA regulatory region 14110 Neighboring gene Sharpr-MPRA regulatory region 13101 Neighboring gene microRNA 548ay Neighboring gene ribosomal protein L31 pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20396

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CKLF-like MARVEL transmembrane domain-containing protein 6
Names
chemokine-like factor super family 6
chemokine-like factor superfamily 6
chemokine-like factor superfamily member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017801.3NP_060271.1  CKLF-like MARVEL transmembrane domain-containing protein 6

    See identical proteins and their annotated locations for NP_060271.1

    Status: REVIEWED

    Source sequence(s)
    AC104306
    Consensus CDS
    CCDS2653.1
    UniProtKB/Swiss-Prot
    Q6IAC4, Q9NX76
    Related
    ENSP00000205636.3, ENST00000205636.4
    Conserved Domains (1) summary
    pfam01284
    Location:58153
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    32481312..32502852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    32478266..32499821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)