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LAX1 lymphocyte transmembrane adaptor 1 [ Homo sapiens (human) ]

Gene ID: 54900, updated on 11-Sep-2019

Summary

Official Symbol
LAX1provided by HGNC
Official Full Name
lymphocyte transmembrane adaptor 1provided by HGNC
Primary source
HGNC:HGNC:26005
See related
Ensembl:ENSG00000122188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAX
Expression
Biased expression in lymph node (RPKM 6.4), appendix (RPKM 5.1) and 13 other tissues See more
Orthologs

Genomic context

See LAX1 in Genome Data Viewer
Location:
1q32.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (203765132..203778175)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (203734284..203745500)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATPase plasma membrane Ca2+ transporting 4 Neighboring gene uncharacterized LOC102723543 Neighboring gene long intergenic non-protein coding RNA 260 Neighboring gene charged multivesicular body protein 5 pseudogene Neighboring gene zinc finger CCCH-type containing 11A Neighboring gene zinc finger BED-type containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of LAX1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20340

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH2 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
antigen receptor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antigen receptor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IDA
Inferred from Direct Assay
more info
PubMed 
immunoglobulin secretion IEA
Inferred from Electronic Annotation
more info
 
inactivation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
lymphocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
NOT membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
lymphocyte transmembrane adapter 1
Names
LAT-like membrane associated protein
linker for activation of x cells
membrane-associated adapter protein LAX

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136190.2NP_001129662.1  lymphocyte transmembrane adapter 1 isoform b

    See identical proteins and their annotated locations for NP_001129662.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC114402, BC089408, DC414389
    Consensus CDS
    CCDS44297.1
    UniProtKB/Swiss-Prot
    Q8IWV1
    Related
    ENSP00000356186.5, ENST00000367217.5
    Conserved Domains (1) summary
    pfam15681
    Location:14381
    LAX; Lymphocyte activation family X
  2. NM_001282878.1NP_001269807.1  lymphocyte transmembrane adapter 1 isoform c

    See identical proteins and their annotated locations for NP_001269807.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter and initiates translation at downstream start codon, compared to variant 1. It encodes isoform c, which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC114402, AK000347, BC089408
    UniProtKB/Swiss-Prot
    Q8IWV1
    Conserved Domains (1) summary
    pfam15681
    Location:1321
    LAX; Lymphocyte activation family X
  3. NM_017773.4NP_060243.2  lymphocyte transmembrane adapter 1 isoform a

    See identical proteins and their annotated locations for NP_060243.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC114402, BC089408, DC414389
    Consensus CDS
    CCDS1441.2
    UniProtKB/Swiss-Prot
    Q8IWV1
    Related
    ENSP00000406970.2, ENST00000442561.6
    Conserved Domains (1) summary
    pfam15681
    Location:29397
    LAX; Lymphocyte activation family X

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    203765132..203778175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711397.3XP_006711460.1  lymphocyte transmembrane adapter 1 isoform X1

    See identical proteins and their annotated locations for XP_006711460.1

    UniProtKB/Swiss-Prot
    Q8IWV1
    Conserved Domains (1) summary
    pfam15681
    Location:29397
    LAX; Lymphocyte activation family X
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