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INO80D INO80 complex subunit D [ Homo sapiens (human) ]

Gene ID: 54891, updated on 26-Nov-2021

Summary

Official Symbol
INO80Dprovided by HGNC
Official Full Name
INO80 complex subunit Dprovided by HGNC
Primary source
HGNC:HGNC:25997
See related
Ensembl:ENSG00000114933 MIM:619207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 2.7), thyroid (RPKM 1.0) and 25 other tissues See more
Orthologs
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Genomic context

See INO80D in Genome Data Viewer
Location:
2q33.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (205993721..206086174, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (206858445..206950898, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 178 Neighboring gene peptidylprolyl isomerase A pseudogene 68 Neighboring gene ribosomal protein L27 pseudogene 8 Neighboring gene Sharpr-MPRA regulatory region 7917 Neighboring gene uncharacterized LOC105373848 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S1 Neighboring gene glycine cleavage system protein H pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Common body mass index-associated variants confer risk of extreme obesity.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20309

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleosome mobilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA strand elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017759.5NP_060229.3  INO80 complex subunit D

    See identical proteins and their annotated locations for NP_060229.3

    Status: VALIDATED

    Source sequence(s)
    AC007679, AK000316, AK096585, BC004193, CR746991, DB233201
    Consensus CDS
    CCDS46500.1
    UniProtKB/Swiss-Prot
    Q53TQ3
    Related
    ENSP00000384198.1, ENST00000403263.6
    Conserved Domains (3) summary
    PRK14971
    Location:211290
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05109
    Location:9141025
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13891
    Location:1879
    zf-C3Hc3H; Potential DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    205993721..206086174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511375.2XP_011509677.1  INO80 complex subunit D isoform X3

    See identical proteins and their annotated locations for XP_011509677.1

    UniProtKB/Swiss-Prot
    Q53TQ3
    Conserved Domains (1) summary
    pfam13891
    Location:342406
    zf-C3Hc3H; Potential DNA-binding domain
  2. XM_011511369.3XP_011509671.1  INO80 complex subunit D isoform X1

    Conserved Domains (1) summary
    pfam13891
    Location:50108
    zf-C3Hc3H; Potential DNA-binding domain
  3. XM_011511376.2XP_011509678.1  INO80 complex subunit D isoform X3

    See identical proteins and their annotated locations for XP_011509678.1

    UniProtKB/Swiss-Prot
    Q53TQ3
    Conserved Domains (1) summary
    pfam13891
    Location:342406
    zf-C3Hc3H; Potential DNA-binding domain
  4. XM_011511371.2XP_011509673.1  INO80 complex subunit D isoform X2

    See identical proteins and their annotated locations for XP_011509673.1

    UniProtKB/Swiss-Prot
    Q53TQ3
    Conserved Domains (3) summary
    PRK14971
    Location:211290
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05109
    Location:9141025
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13891
    Location:1879
    zf-C3Hc3H; Potential DNA-binding domain
  5. XM_011511370.2XP_011509672.1  INO80 complex subunit D isoform X2

    See identical proteins and their annotated locations for XP_011509672.1

    UniProtKB/Swiss-Prot
    Q53TQ3
    Conserved Domains (3) summary
    PRK14971
    Location:211290
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05109
    Location:9141025
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13891
    Location:1879
    zf-C3Hc3H; Potential DNA-binding domain
  6. XM_011511373.3XP_011509675.1  INO80 complex subunit D isoform X2

    See identical proteins and their annotated locations for XP_011509675.1

    UniProtKB/Swiss-Prot
    Q53TQ3
    Conserved Domains (3) summary
    PRK14971
    Location:211290
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05109
    Location:9141025
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13891
    Location:1879
    zf-C3Hc3H; Potential DNA-binding domain

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_015495299.1 Reference GRCh38.p13 PATCHES

    Range
    102739..195192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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