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SNRK SNF related kinase [ Homo sapiens (human) ]

Gene ID: 54861, updated on 5-Aug-2018

Summary

Official Symbol
SNRKprovided by HGNC
Official Full Name
SNF related kinaseprovided by HGNC
Primary source
HGNC:HGNC:30598
See related
Ensembl:ENSG00000163788 MIM:612760; Vega:OTTHUMG00000156491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSNFRK
Summary
SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 23.2), thyroid (RPKM 20.1) and 25 other tissues See more
Orthologs

Genomic context

See SNRK in Genome Data Viewer
Location:
3p22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (43286512..43351143)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (43328004..43392635)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory regions 3209 and 6245 Neighboring gene uncharacterized LOC105377052 Neighboring gene RNA, 7SL, cytoplasmic 517, pseudogene Neighboring gene SNRK antisense RNA 1 Neighboring gene anoctamin 10 Neighboring gene uncharacterized LOC107986080 Neighboring gene ribosomal protein L18a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20224, KIAA0096, DKFZp779A1866

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myeloid cell differentiation TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
SNF-related serine/threonine-protein kinase
Names
SNF-1 related kinase
SNF1-related kinase
NP_001094064.1
NP_001317679.1
NP_060189.3
XP_005265302.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100594.1NP_001094064.1  SNF-related serine/threonine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_001094064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK025449, BC071567, D43636, DA769463, DB080037
    Consensus CDS
    CCDS43075.1
    UniProtKB/Swiss-Prot
    Q9NRH2
    UniProtKB/TrEMBL
    A0A024R2Y6
    Related
    ENSP00000411375.2, OTTHUMP00000209955, ENST00000429705.6, OTTHUMT00000344323
    Conserved Domains (3) summary
    smart00220
    Location:16269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14339
    Location:288335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase
  2. NM_001330750.1NP_001317679.1  SNF-related serine/threonine-protein kinase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK025449, AK291360, AK295187, D43636
    Consensus CDS
    CCDS82759.1
    UniProtKB/Swiss-Prot
    Q9NRH2
    UniProtKB/TrEMBL
    A8K5P5, B4DHM9, E7EUC4
    Related
    ENSP00000409516.1, ENST00000437827.1
    Conserved Domains (2) summary
    cd14339
    Location:82129
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cl21453
    Location:163
    PKc_like; Protein Kinases, catalytic domain
  3. NM_017719.4NP_060189.3  SNF-related serine/threonine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_060189.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK025449, BP281284, D43636, DA769463, DB080037
    Consensus CDS
    CCDS43075.1
    UniProtKB/Swiss-Prot
    Q9NRH2
    UniProtKB/TrEMBL
    A0A024R2Y6
    Related
    ENSP00000296088.7, OTTHUMP00000209957, ENST00000296088.11, OTTHUMT00000344325
    Conserved Domains (3) summary
    smart00220
    Location:16269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14339
    Location:288335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    43286512..43351143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265245.3XP_005265302.1  SNF-related serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_005265302.1

    UniProtKB/Swiss-Prot
    Q9NRH2
    UniProtKB/TrEMBL
    A0A024R2Y6
    Related
    ENSP00000401246.1, OTTHUMP00000209954, ENST00000454177.5, OTTHUMT00000344322
    Conserved Domains (3) summary
    smart00220
    Location:16269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14339
    Location:288335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase
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