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SNRK SNF related kinase [ Homo sapiens (human) ]

Gene ID: 54861, updated on 6-Nov-2022

Summary

Official Symbol
SNRKprovided by HGNC
Official Full Name
SNF related kinaseprovided by HGNC
Primary source
HGNC:HGNC:30598
See related
Ensembl:ENSG00000163788 MIM:612760; AllianceGenome:HGNC:30598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSNFRK
Summary
SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 23.2), thyroid (RPKM 20.1) and 25 other tissues See more
Orthologs
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Genomic context

See SNRK in Genome Data Viewer
Location:
3p22.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (43286540..43351143)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (43301847..43366451)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (43328032..43392635)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory regions 3209 and 6245 Neighboring gene uncharacterized LOC105377052 Neighboring gene RNA, 7SL, cytoplasmic 517, pseudogene Neighboring gene SNRK antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1625 Neighboring gene anoctamin 10 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:43496575-43497774

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20224, KIAA0096, DKFZp779A1866

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myeloid cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
SNF-related serine/threonine-protein kinase
Names
SNF-1 related kinase
SNF1-related kinase
NP_001094064.1
NP_001317679.1
NP_060189.3
XP_005265302.1
XP_047304352.1
XP_047304353.1
XP_047304354.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100594.2NP_001094064.1  SNF-related serine/threonine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_001094064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK025449, BC071567, D43636, DA769463, DB080037
    Consensus CDS
    CCDS43075.1
    UniProtKB/Swiss-Prot
    Q9NRH2, Q9NXI7
    UniProtKB/TrEMBL
    A0A024R2Y6
    Related
    ENSP00000411375.2, ENST00000429705.6
    Conserved Domains (2) summary
    cd14339
    Location:288335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase
  2. NM_001330750.2NP_001317679.1  SNF-related serine/threonine-protein kinase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK025449, AK291360, AK295187, D43636
    Consensus CDS
    CCDS82759.1
    UniProtKB/Swiss-Prot
    Q9NRH2
    UniProtKB/TrEMBL
    A8K5P5, B4DHM9, E7EUC4
    Related
    ENSP00000409516.1, ENST00000437827.1
    Conserved Domains (2) summary
    cd14339
    Location:82129
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cl21453
    Location:163
    PKc_like; Protein Kinases, catalytic domain
  3. NM_017719.5NP_060189.3  SNF-related serine/threonine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_060189.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK025449, BP281284, D43636, DB080037
    Consensus CDS
    CCDS43075.1
    UniProtKB/Swiss-Prot
    Q9NRH2, Q9NXI7
    UniProtKB/TrEMBL
    A0A024R2Y6
    Related
    ENSP00000296088.7, ENST00000296088.12
    Conserved Domains (2) summary
    cd14339
    Location:288335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    43286540..43351143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448396.1XP_047304352.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q9NXI7
    UniProtKB/TrEMBL
    A0A024R2Y6
  2. XM_005265245.4XP_005265302.1  SNF-related serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_005265302.1

    UniProtKB/Swiss-Prot
    Q9NRH2, Q9NXI7
    UniProtKB/TrEMBL
    A0A024R2Y6
    Related
    ENSP00000401246.1, ENST00000454177.5
    Conserved Domains (2) summary
    cd14339
    Location:288335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase
  3. XM_047448397.1XP_047304353.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q9NXI7
    UniProtKB/TrEMBL
    A0A024R2Y6
  4. XM_047448398.1XP_047304354.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q9NXI7
    UniProtKB/TrEMBL
    A0A024R2Y6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    43301847..43366451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)