Format

Send to:

Choose Destination

CDHR2 cadherin related family member 2 [ Homo sapiens (human) ]

Gene ID: 54825, updated on 12-Oct-2019

Summary

Official Symbol
CDHR2provided by HGNC
Official Full Name
cadherin related family member 2provided by HGNC
Primary source
HGNC:HGNC:18231
See related
Ensembl:ENSG00000074276
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCLKC; PCDH24
Summary
This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. This protocadherin represents a new candidate for tumor suppression. Alternatively spliced transcript variants that encode the same protein have been identified. [provided by RefSeq, Jan 2010]
Expression
Biased expression in duodenum (RPKM 125.9), small intestine (RPKM 110.9) and 3 other tissues See more
Orthologs

Genomic context

See CDHR2 in Genome Data Viewer
Location:
5q35.2
Exon count:
33
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (176542511..176595974)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (175969512..176022769)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 10 Neighboring gene clathrin light chain B Neighboring gene Fas associated factor family member 2 Neighboring gene collagen alpha-1(III) chain-like Neighboring gene ring finger protein 44 Neighboring gene RNA, 7SL, cytoplasmic 684, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11151 Neighboring gene G protein regulated inducer of neurite outgrowth 1 Neighboring gene microRNA 4281 Neighboring gene synuclein beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20124, FLJ20383, MGC163154

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion molecule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion mediated by cadherin IDA
Inferred from Direct Assay
more info
PubMed 
epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
intermicrovillar adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth involved in contact inhibition IDA
Inferred from Direct Assay
more info
PubMed 
regulation of microvillus length IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
brush border IDA
Inferred from Direct Assay
more info
PubMed 
brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
microvillus membrane IDA
Inferred from Direct Assay
more info
PubMed 
spanning component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cadherin-related family member 2
Names
protocadherin-24

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171976.1NP_001165447.1  cadherin-related family member 2 precursor

    See identical proteins and their annotated locations for NP_001165447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB047004, AC091934, AK225217, AK315055
    Consensus CDS
    CCDS34297.1
    UniProtKB/Swiss-Prot
    Q9BYE9
    Related
    ENSP00000424565.1, ENST00000510636.5
    Conserved Domains (2) summary
    cd11304
    Location:485582
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:864926
    CA; Cadherin repeats
  2. NM_017675.5NP_060145.3  cadherin-related family member 2 precursor

    See identical proteins and their annotated locations for NP_060145.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB047004, AC091934, AK225217, AK315055, BP271197
    Consensus CDS
    CCDS34297.1
    UniProtKB/Swiss-Prot
    Q9BYE9
    Related
    ENSP00000261944.5, ENST00000261944.9
    Conserved Domains (2) summary
    cd11304
    Location:485582
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:864926
    CA; Cadherin repeats

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    176542511..176595974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center