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Cdhr2 cadherin-related family member 2 [ Mus musculus (house mouse) ]

Gene ID: 268663, updated on 9-Mar-2023

Summary

Official Symbol
Cdhr2provided by MGI
Official Full Name
cadherin-related family member 2provided by MGI
Primary source
MGI:MGI:2687323
See related
Ensembl:ENSMUSG00000034918 AllianceGenome:MGI:2687323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm624; PC-LKC; Pcdh24
Summary
Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by cadherin; intermicrovillar adhesion; and negative regulation of cell growth involved in contact inhibition. Predicted to act upstream of or within cell differentiation. Predicted to be located in apical plasma membrane; brush border membrane; and microvillus membrane. Predicted to be spanning component of plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human CDHR2 (cadherin related family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 326.0), duodenum adult (RPKM 242.2) and 3 other tissues See more
Orthologs
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Genomic context

See Cdhr2 in Genome Data Viewer
Location:
13; 13 B1
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54849276..54884475)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54701463..54736662)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Fas associated factor family member 2 Neighboring gene 4.5s RNA, pseudogene 3 Neighboring gene ring finger protein 44 Neighboring gene G protein-regulated inducer of neurite outgrowth 1 Neighboring gene synuclein, beta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
involved_in intermicrovillar adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth involved in contact inhibition ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microvillus length ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cadherin-related family member 2
Names
protocadherin 24
protocadherin LKC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033364.3NP_001028536.2  cadherin-related family member 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK144400, BC141301, BX630481
    Consensus CDS
    CCDS36669.1
    UniProtKB/Swiss-Prot
    E9Q7P9, Q3UN77
    Related
    ENSMUSP00000043596.8, ENSMUST00000037145.8
    Conserved Domains (1) summary
    cd11304
    Location:485582
    Cadherin_repeat; Cadherin tandem repeat domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54849276..54884475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)