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MED18 mediator complex subunit 18 [ Homo sapiens (human) ]

Gene ID: 54797, updated on 25-Nov-2021

Summary

Official Symbol
MED18provided by HGNC
Official Full Name
mediator complex subunit 18provided by HGNC
Primary source
HGNC:HGNC:25944
See related
Ensembl:ENSG00000130772 MIM:612384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRB5; p28b
Summary
MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
Expression
Ubiquitous expression in colon (RPKM 5.4), lymph node (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

See MED18 in Genome Data Viewer
Location:
1p35.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (28329040..28335967)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28655551..28662476)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATP synthase inhibitory factor subunit 1 Neighboring gene sestrin 2 Neighboring gene Sharpr-MPRA regulatory region 70 Neighboring gene phosphatase and actin regulator 4 Neighboring gene Sharpr-MPRA regulatory region 2241

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat 47-59 peptide upregulates gene expression of mediator complex subunit 18 (MED18) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20045

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in termination of RNA polymerase II transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 18
Names
TRAP/mediator complex subunit p28b
mediator of RNA polymerase II transcription, subunit 18 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127350.2NP_001120822.1  mediator of RNA polymerase II transcription subunit 18

    See identical proteins and their annotated locations for NP_001120822.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL353622, BG752399
    Consensus CDS
    CCDS322.1
    UniProtKB/Swiss-Prot
    Q9BUE0
    Conserved Domains (1) summary
    pfam09637
    Location:19207
    Med18; Med18 protein
  2. NM_017638.3NP_060108.2  mediator of RNA polymerase II transcription subunit 18

    See identical proteins and their annotated locations for NP_060108.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK000052, AL353622
    Consensus CDS
    CCDS322.1
    UniProtKB/Swiss-Prot
    Q9BUE0
    Related
    ENSP00000362948.4, ENST00000373842.9
    Conserved Domains (1) summary
    pfam09637
    Location:19207
    Med18; Med18 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    28329040..28335967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245914.4XP_005245971.1  mediator of RNA polymerase II transcription subunit 18 isoform X1

    See identical proteins and their annotated locations for XP_005245971.1

    UniProtKB/Swiss-Prot
    Q9BUE0
    Conserved Domains (1) summary
    pfam09637
    Location:19207
    Med18; Med18 protein

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654706.1 Reference GRCh38.p13 PATCHES

    Range
    122684..129609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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