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MED18 mediator complex subunit 18 [ Homo sapiens (human) ]

Gene ID: 54797, updated on 2-Nov-2024

Summary

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Official Symbol
MED18provided by HGNC
Official Full Name
mediator complex subunit 18provided by HGNC
Primary source
HGNC:HGNC:25944
See related
Ensembl:ENSG00000130772 MIM:612384; AllianceGenome:HGNC:25944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRB5; p28b
Summary
MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
Expression
Ubiquitous expression in colon (RPKM 5.4), lymph node (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

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See MED18 in Genome Data Viewer
Location:
1p35.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (28329040..28335965)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (28170876..28177801)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28655551..28662476)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28572195-28572694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 593 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28576752-28577625 Neighboring gene ATP synthase inhibitory factor subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28585772-28586620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 537 Neighboring gene sestrin 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:28616419-28617413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28640148-28640648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28655585-28656092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28656093-28656600 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28695423-28696378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 538 Neighboring gene phosphatase and actin regulator 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:28726665-28726882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 539 Neighboring gene Sharpr-MPRA regulatory region 2241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 540 Neighboring gene RNA, U6atac small nuclear 27, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7965 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28833855-28834620 Neighboring gene small nucleolar RNA, H/ACA box 73A Neighboring gene small nucleolar RNA host gene 3 Neighboring gene regulator of chromosome condensation 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module. Kumafuji M, et al. Genes Cells, 2014 Jul. PMID 24840924
  2. Dermatomyositis presenting with focal scleroderma-like skin changes. Chai Y, et al. J Clin Neuromuscul Dis, 2012 Jun. PMID 22622162
  3. Long non-coding RNA SNHG3 promotes progression of gastric cancer by regulating neighboring MED18 gene methylation. Xuan Y, et al. Cell Death Dis, 2019 Sep 18. PMID 31534128, Free PMC Article
  4. Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression. Young ET, et al. Mol Cell Biol, 2008 Apr. PMID 18250152, Free PMC Article
  5. A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. Sato S, et al. J Biol Chem, 2003 Dec 12. PMID 14576168

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA SNHG3 promotes progression of gastric cancer by regulating neighboring MED18 gene methylation.
    Title: Long non-coding RNA SNHG3 promotes progression of gastric cancer by regulating neighboring MED18 gene methylation.
  2. A novel transcriptional repression mechanism of hMED18 mediated by hCDK8 and further a novel positive role of free CDK/cyclin module in transcriptional activation is described.
    Title: Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat 47-59 peptide upregulates gene expression of mediator complex subunit 18 (MED18) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20045

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 18
Names
TRAP/mediator complex subunit p28b
mediator of RNA polymerase II transcription, subunit 18 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127350.2 → NP_001120822.1  mediator of RNA polymerase II transcription subunit 18

    See identical proteins and their annotated locations for NP_001120822.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL353622, BG752399
    Consensus CDS
    CCDS322.1
    UniProtKB/Swiss-Prot
    D3DPM1, Q9BUE0, Q9NXU9
    UniProtKB/TrEMBL
    B4DJL3
    Conserved Domains (1) summary
    pfam09637
    Location:19 → 207
    Med18; Med18 protein

  2. NM_017638.3 → NP_060108.2  mediator of RNA polymerase II transcription subunit 18

    See identical proteins and their annotated locations for NP_060108.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK000052, AL353622
    Consensus CDS
    CCDS322.1
    UniProtKB/Swiss-Prot
    D3DPM1, Q9BUE0, Q9NXU9
    UniProtKB/TrEMBL
    B4DJL3
    Related
    ENSP00000362948.4, ENST00000373842.9
    Conserved Domains (1) summary
    pfam09637
    Location:19 → 207
    Med18; Med18 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    28329040..28335965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245914.5 → XP_005245971.1  mediator of RNA polymerase II transcription subunit 18 isoform X1

    See identical proteins and their annotated locations for XP_005245971.1

    UniProtKB/Swiss-Prot
    D3DPM1, Q9BUE0, Q9NXU9
    UniProtKB/TrEMBL
    B4DJL3
    Conserved Domains (1) summary
    pfam09637
    Location:19 → 207
    Med18; Med18 protein

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654706.1 Reference GRCh38.p14 PATCHES

    Range
    122684..129609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332155.1 → XP_054188130.1  mediator of RNA polymerase II transcription subunit 18 isoform X1

    UniProtKB/Swiss-Prot
    D3DPM1, Q9BUE0, Q9NXU9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    28170876..28177801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337204.1 → XP_054193179.1  mediator of RNA polymerase II transcription subunit 18 isoform X1

    UniProtKB/Swiss-Prot
    D3DPM1, Q9BUE0, Q9NXU9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BUE0.1 GenPept UniProtKB/Swiss-Prot:Q9BUE0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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