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LEPROT leptin receptor overlapping transcript [ Homo sapiens (human) ]

Gene ID: 54741, updated on 9-Jun-2025
Official Symbol
LEPROTprovided by HGNC
Official Full Name
leptin receptor overlapping transcriptprovided by HGNC
Primary source
HGNC:HGNC:29477
See related
Ensembl:ENSG00000213625 MIM:613461; AllianceGenome:HGNC:29477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEPR; VPS55; OBRGRP; OB-RGRP
Summary
LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]
Expression
Ubiquitous expression in fat (RPKM 33.5), kidney (RPKM 30.3) and 25 other tissues See more
Orthologs
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See LEPROT in Genome Data Viewer
Location:
1p31.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (65420668..65436007)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (65298645..65313980)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (65886351..65901690)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene uncharacterized LOC112268227 Neighboring gene Sharpr-MPRA regulatory region 12103 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:65885665-65886197 and GRCh37_chr1:65886198-65886731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1144 Neighboring gene RNA, U2 small nuclear 15, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13002 Neighboring gene leptin receptor Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:65933067-65933623 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:66019858-66020504 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:66029333-66029958 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:66029959-66030582 Neighboring gene small nucleolar RNA U13 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11 pseudogene

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ37482, FLJ90360

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
leptin receptor gene-related protein
Names
DnaJ (Hsp40) homolog, subfamily C, member 6
OB-R gene-related protein
endospanin
endospanin-1
leptin receptor overlapping transcript protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198681.2NP_001185610.1  leptin receptor gene-related protein isoform 2

    See identical proteins and their annotated locations for NP_001185610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' region, as compared to variant 1. The resulting isoform (2) has a longer and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC119800, AK309370
    Consensus CDS
    CCDS72801.1
    UniProtKB/TrEMBL
    A0A087X0N2
    Related
    ENSP00000483521.1, ENST00000613538.1
    Conserved Domains (1) summary
    pfam04133
    Location:16133
    Vps55; Vacuolar protein sorting 55
  2. NM_001198683.2NP_001185612.1  leptin receptor gene-related protein isoform 3

    See identical proteins and their annotated locations for NP_001185612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 3' sequence, as compared to variant 1. The resulting isoform (3) is much shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK074841, BC140007
    UniProtKB/Swiss-Prot
    O15243
    Related
    ENST00000497874.5
    Conserved Domains (1) summary
    pfam04133
    Location:727
    Vps55; Vacuolar protein sorting 55
  3. NM_017526.5NP_059996.1  leptin receptor gene-related protein isoform 1

    See identical proteins and their annotated locations for NP_059996.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is dominant and encodes the shorter isoform (1).
    Source sequence(s)
    AC119800, CA434795, Y12670
    Consensus CDS
    CCDS630.1
    UniProtKB/Swiss-Prot
    O15243, Q6FHL5
    UniProtKB/TrEMBL
    A0A3B3ISI8
    Related
    ENSP00000360104.4, ENST00000371065.9
    Conserved Domains (1) summary
    pfam04133
    Location:7124
    Vps55; Vacuolar protein sorting 55

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    65420668..65436007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    65298645..65313980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)