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Prdx5 peroxiredoxin 5 [ Mus musculus (house mouse) ]

Gene ID: 54683, updated on 8-Feb-2024

Summary

Official Symbol
Prdx5provided by MGI
Official Full Name
peroxiredoxin 5provided by MGI
Primary source
MGI:MGI:1859821
See related
Ensembl:ENSMUSG00000024953 AllianceGenome:MGI:1859821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PLP; AOPP; PrxV; Pmp20; Prdx6; AOEB166
Summary
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites may result in use of alternate in-frame translation start codons that generate alternate isoforms that are targeted to the mitochondrion or peroxisome/cytoplasm. [provided by RefSeq, Nov 2017]
Expression
Ubiquitous expression in kidney adult (RPKM 737.0), heart adult (RPKM 197.2) and 27 other tissues See more
Orthologs
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Genomic context

See Prdx5 in Genome Data Viewer
Location:
19 A; 19 5.08 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6884065..6887474, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6906697..6910106, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 88B Neighboring gene predicted gene, 54051 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:6946569-6946770 Neighboring gene tRNA methyltransferase 11-2 Neighboring gene estrogen related receptor, alpha Neighboring gene microRNA 6990 Neighboring gene STARR-positive B cell enhancer ABC_E780 Neighboring gene cation channel sperm associated auxiliary subunit zeta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase III transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables antioxidant activity ISO
Inferred from Sequence Orthology
more info
 
enables antioxidant activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peroxynitrite reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thioredoxin peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables thioredoxin-dependent peroxiredoxin activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in NADPH oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hydrogen peroxide catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in reactive nitrogen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptosis involved in tissue homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxiredoxin-5, mitochondrial
Names
antioxidant enzyme B166
liver tissue 2D-page spot 2D-0014IV
peroxiredoxin 6
peroxiredoxin V
peroxisomal antioxidant enzyme
peroxisomal membrane protein 20
thioredoxin peroxidase PMP20
thioredoxin reductase
thioredoxin-dependent peroxiredoxin 5
NP_001345373.1
NP_036151.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358444.1NP_001345373.1  peroxiredoxin-5, mitochondrial isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus than isoform 1.
    Source sequence(s)
    AC120557
    UniProtKB/TrEMBL
    A0A494BAZ4
    Related
    ENSMUSP00000158249.2, ENSMUST00000238095.2
    Conserved Domains (1) summary
    cd03013
    Location:54155
    PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
  2. NM_012021.3NP_036151.1  peroxiredoxin-5, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_036151.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA208558, AC120557, AK003332, AK009858
    Consensus CDS
    CCDS29507.1
    UniProtKB/Swiss-Prot
    P99029, Q9QX45, Q9QZ75
    UniProtKB/TrEMBL
    Q3U7H9
    Related
    ENSMUSP00000025904.6, ENSMUST00000025904.12
    Conserved Domains (1) summary
    cd03013
    Location:54208
    PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6884065..6887474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)