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PRDX5 peroxiredoxin 5 [ Homo sapiens (human) ]

Gene ID: 25824, updated on 4-Oct-2020

Summary

Official Symbol
PRDX5provided by HGNC
Official Full Name
peroxiredoxin 5provided by HGNC
Primary source
HGNC:HGNC:9355
See related
Ensembl:ENSG00000126432 MIM:606583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLP; ACR1; B166; PRXV; PMP20; PRDX6; prx-V; SBBI10; AOEB166; HEL-S-55
Summary
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]
Expression
Ubiquitous expression in colon (RPKM 157.0), kidney (RPKM 130.3) and 25 other tissues See more
Orthologs

Genomic context

See PRDX5 in Genome Data Viewer
Location:
11q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64318121..64321811)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64085347..64089295)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene KCNK4-TEX40 readthrough Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene estrogen related receptor alpha Neighboring gene tRNA methyltransferase subunit 11-2 Neighboring gene uncharacterized LOC102723878 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3041 Neighboring gene coiled-coil domain containing 88B Neighboring gene microRNA 7155

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1.
GeneReviews: Not available
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
GeneReviews: Not available
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117264, MGC142283, MGC142285

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase III regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thioredoxin peroxidase activity EXP
Inferred from Experiment
more info
PubMed 
thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to oxidative stress TAS
Traceable Author Statement
more info
 
cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxiredoxin-5, mitochondrial
Names
Alu co-repressor 1
TPx type VI
antioxidant enzyme B166
epididymis secretory protein Li 55
liver tissue 2D-page spot 71B
peroxiredoxin V
peroxisomal antioxidant enzyme
thioredoxin peroxidase PMP20
thioredoxin reductase
thioredoxin-dependent peroxiredoxin 5
NP_001345440.2
NP_001345445.1
NP_036226.2
NP_857634.2
NP_857635.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358511.2NP_001345440.2  peroxiredoxin-5, mitochondrial isoform d precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (d) is shorter than isoform L.
    Source sequence(s)
    AP001453, AP003774
    Conserved Domains (1) summary
    cd03013
    Location:57167
    PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
  2. NM_001358516.2NP_001345445.1  peroxiredoxin-5, mitochondrial isoform S

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents use of an internal transcription start site determined in PMID:17628720 compared to variant 1. It initiates translation at an in-frame downstream start codon and encodes isoform S, which has a shorter N-terminus lacking the mitochondrial transit peptide found in isoform L.
    Source sequence(s)
    AF112212, AF124993, AF197952, AF242525, AP001453
    Conserved Domains (1) summary
    cd03013
    Location:6160
    PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
  3. NM_012094.5NP_036226.2  peroxiredoxin-5, mitochondrial isoform L precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (L).
    Source sequence(s)
    AP001453, AP003774
    Consensus CDS
    CCDS8069.1
    Related
    ENSP00000265462.4, ENST00000265462.9
    Conserved Domains (1) summary
    cd03013
    Location:58212
    PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
  4. NM_181651.3NP_857634.2  peroxiredoxin-5, mitochondrial isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) is shorter than isoform L.
    Source sequence(s)
    AP001453, AP003774
    Consensus CDS
    CCDS8070.1
    Related
    ENSP00000335334.6, ENST00000352435.8
    Conserved Domains (1) summary
    cl00388
    Location:58168
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  5. NM_181652.3NP_857635.2  peroxiredoxin-5, mitochondrial isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (c) is shorter than isoform L.
    Source sequence(s)
    AP001453, AP003774
    Consensus CDS
    CCDS8071.1
    Related
    ENSP00000335363.6, ENST00000347941.4
    Conserved Domains (1) summary
    cl00388
    Location:57123
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64318121..64321811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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