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Ccdc22 coiled-coil domain containing 22 [ Mus musculus (house mouse) ]

Gene ID: 54638, updated on 5-Mar-2024

Summary

Official Symbol
Ccdc22provided by MGI
Official Full Name
coiled-coil domain containing 22provided by MGI
Primary source
MGI:MGI:1859608
See related
Ensembl:ENSMUSG00000031143 AllianceGenome:MGI:1859608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sfc22; Ppp1r3f; DXImx40e
Summary
Predicted to enable cullin family protein binding activity. Predicted to be involved in several processes, including cytoplasmic sequestering of NF-kappaB; regulation of I-kappaB kinase/NF-kappaB signaling; and vesicle-mediated transport to the plasma membrane. Predicted to act upstream of or within cholesterol homeostasis and regulation of plasma lipoprotein particle levels. Predicted to be located in endosome. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 2. Orthologous to human CCDC22 (coiled-coil domain containing 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 12.7), thymus adult (RPKM 12.7) and 28 other tissues See more
Orthologs
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Genomic context

See Ccdc22 in Genome Data Viewer
Location:
X A1.1; X 3.42 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7460048..7471659, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7593809..7605420, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 23082 Neighboring gene protein phosphatase 1, regulatory subunit 3F Neighboring gene STARR-positive B cell enhancer mm9_chrX:7151387-7151688 Neighboring gene Foxp3 regulating long intergenic noncoding RNA Neighboring gene forkhead box P3 Neighboring gene calcium channel, voltage-dependent, alpha 1F subunit Neighboring gene STARR-positive B cell enhancer ABC_E1215 Neighboring gene synaptophysin Neighboring gene predicted gene 14703

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
coiled-coil domain-containing protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138603.3NP_613069.3  coiled-coil domain-containing protein 22

    See identical proteins and their annotated locations for NP_613069.3

    Status: VALIDATED

    Source sequence(s)
    AF229637, BM936498, BY136942
    Consensus CDS
    CCDS29966.1
    UniProtKB/Swiss-Prot
    B1AVA1, Q8BYH4, Q9JIG7
    Related
    ENSMUSP00000033483.5, ENSMUST00000033483.5
    Conserved Domains (1) summary
    pfam05667
    Location:1590
    DUF812; Protein of unknown function (DUF812)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7460048..7471659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)