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St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [ Mus musculus (house mouse) ]

Gene ID: 54613, updated on 8-Dec-2022

Summary

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Official Symbol
St3gal6provided by MGI
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 6provided by MGI
Primary source
MGI:MGI:1888707
See related
Ensembl:ENSMUSG00000022747 AllianceGenome:MGI:1888707
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat10; St3galVI; 1700023B24Rik
Summary
Predicted to enable beta-galactoside alpha-2,3-sialyltransferase activity. Predicted to be involved in glycolipid metabolic process; oligosaccharide metabolic process; and protein glycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in early tubule. Orthologous to human ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 4.2), lung adult (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See St3gal6 in Genome Data Viewer
Location:
16; 16 C1.2
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (58290105..58344616, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (58469742..58524260, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41463 Neighboring gene RIKEN cDNA 4930461C15 gene Neighboring gene discoidin, CUB and LCCL domain containing 2 Neighboring gene predicted gene, 20942 Neighboring gene ferritin domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands. Yang WH, et al. Blood, 2012 Aug 2. PMID 22700726, Free PMC Article
  2. Combinatorial PCR approach to homology-based cloning: cloning and expression of mouse and human GM3-synthase. Kapitonov D, et al. Glycoconj J, 1999 Jul. PMID 10619706
  3. Comparison of genomic structures of four members of beta-galactoside alpha2,3-sialyltransferase genes in the mouse. Takashima S, et al. Cytogenet Cell Genet, 2000. PMID 10894948
  4. Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis. Yang WH, et al. Cell Host Microbe, 2018 Oct 10. PMID 30308156, Free PMC Article
  5. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article

See all (23) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coordinated participation of both ST3Gal-VI and ST3Gal-IV in the synthesis of functional selectin ligands.
    Title: Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-galactoside alpha-2,3-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables beta-galactoside alpha-2,3-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in glycolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein modification process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sialylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
type 2 lactosamine alpha-2,3-sialyltransferase
Names
CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
ST3Gal VI
alpha-2,3-sialyltransferase VI
sialyltransferase 10 (alpha-2,3-sialyltransferase VI)
NP_001344362.1
NP_001344363.1
NP_001344364.1
NP_061254.1
XP_011244274.1
XP_011244275.1
XP_011244276.1
XP_011244277.1
XP_011244278.1
XP_030105054.1
XP_036015918.1
XP_036015919.1
XP_036015920.1
XP_036015921.1
XP_036015922.1
XP_036015923.1
XP_036015924.1
XP_036015925.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357433.2 → NP_001344362.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    Consensus CDS
    CCDS28230.1
    UniProtKB/Swiss-Prot
    Q9WVG2
    Related
    ENSMUSP00000109998.3, ENSMUST00000114358.9
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_001357434.2 → NP_001344363.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    Conserved Domains (1) summary
    pfam00777
    Location:69 → 318
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. NM_001357435.2 → NP_001344364.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    Consensus CDS
    CCDS28230.1
    UniProtKB/Swiss-Prot
    Q9WVG2
    Related
    ENSMUSP00000109997.4, ENSMUST00000114357.10
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. NM_001403132.1 → NP_001390061.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    UniProtKB/Swiss-Prot
    Q9WVG2

  5. NM_001403133.1 → NP_001390062.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    UniProtKB/Swiss-Prot
    Q9WVG2

  6. NM_001403134.1 → NP_001390063.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    UniProtKB/Swiss-Prot
    Q9WVG2

  7. NM_001403135.1 → NP_001390064.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT027564
    UniProtKB/Swiss-Prot
    Q9WVG2

  8. NM_001403136.1 → NP_001390065.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564

  9. NM_001403137.1 → NP_001390066.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT027564

  10. NM_018784.3 → NP_061254.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    See identical proteins and their annotated locations for NP_061254.1

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564
    Consensus CDS
    CCDS28230.1
    UniProtKB/Swiss-Prot
    Q8VIB3, Q9WVG2
    Related
    ENSMUSP00000115756.2, ENSMUST00000137035.8
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_175353.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564

  2. NR_175354.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564

  3. NR_175355.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564

  4. NR_175356.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154764, CT027564

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    58290105..58344616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245975.3 → XP_011244277.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:69 → 318
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_036160029.1 → XP_036015922.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    UniProtKB/Swiss-Prot
    Q9WVG2
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_036160028.1 → XP_036015921.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    UniProtKB/Swiss-Prot
    Q9WVG2
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. XM_036160030.1 → XP_036015923.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    UniProtKB/Swiss-Prot
    Q9WVG2
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. XM_036160026.1 → XP_036015919.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:129 → 378
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  6. XM_036160025.1 → XP_036015918.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:139 → 388
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  7. XM_030249194.1 → XP_030105054.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X7

    Conserved Domains (1) summary
    pfam00777
    Location:5 → 254
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  8. XM_011245972.4 → XP_011244274.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    UniProtKB/Swiss-Prot
    Q8VIB3
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  9. XM_011245973.3 → XP_011244275.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    UniProtKB/Swiss-Prot
    Q8VIB3
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  10. XM_036160032.1 → XP_036015925.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    UniProtKB/Swiss-Prot
    Q9WVG2
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  11. XM_011245974.4 → XP_011244276.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    See identical proteins and their annotated locations for XP_011244276.1

    UniProtKB/Swiss-Prot
    Q8VIB3, Q9WVG2
    Conserved Domains (1) summary
    pfam00777
    Location:79 → 328
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  12. XM_036160031.1 → XP_036015924.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X6

    Conserved Domains (1) summary
    pfam00777
    Location:79 → 303
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  13. XM_011245976.4 → XP_011244278.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X6

    Conserved Domains (1) summary
    pfam00777
    Location:79 → 303
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  14. XM_036160027.1 → XP_036015920.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:139 → 363
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_384577.5 RNA Sequence

  2. XR_003951805.2 RNA Sequence

  3. XR_003951802.2 RNA Sequence

  4. XR_004939201.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VIB3.3 GenPept UniProtKB/Swiss-Prot:Q8VIB3

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