Format

Send to:

Choose Destination

ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 10402, updated on 1-Aug-2020

Summary

Official Symbol
ST3GAL6provided by HGNC
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:18080
See related
Ensembl:ENSG00000064225 MIM:607156
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAT10; ST3GALVI
Summary
The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. [provided by RefSeq, Apr 2016]
Expression
Broad expression in heart (RPKM 8.2), liver (RPKM 7.6) and 24 other tissues See more
Orthologs

Genomic context

See ST3GAL6 in Genome Data Viewer
Location:
3q12.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (98732236..98795845)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (98451080..98514689)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19 pseudogene 7 Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 pseudogene 1 Neighboring gene ST3GAL6 antisense RNA 1 Neighboring gene PDZ and LIM domain 1 pseudogene 4 Neighboring gene discoidin, CUB and LCCL domain containing 2 Neighboring gene RNA, U6 small nuclear 26, pseudogene Neighboring gene uncharacterized LOC105374002

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-galactoside alpha-2,3-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-galactoside alpha-2,3-sialyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular protein modification process IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-6 IEP
Inferred from Expression Pattern
more info
PubMed 
glycolipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
oligosaccharide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sialylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
type 2 lactosamine alpha-2,3-sialyltransferase
Names
CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
alpha2,3-sialyltransferase ST3Gal VI
sialyltransferase 10 (alpha-2,3-sialyltransferase VI)
NP_001258071.1
NP_001258074.1
NP_001258075.1
NP_001258076.1
NP_001258077.1
NP_001310281.1
NP_001310282.1
NP_001310287.1
NP_001310288.1
NP_001310289.1
NP_001310291.1
NP_001310292.1
NP_001310293.1
NP_001310294.1
NP_001310295.1
NP_001310296.1
NP_001310297.1
NP_006091.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271142.1NP_001258071.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001258071.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2, 10 and 11 encode the same isoform (2).
    Source sequence(s)
    AC106728, BC001266, DB036799
    Conserved Domains (1) summary
    pfam00777
    Location:1243
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001271145.1NP_001258074.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 3

    See identical proteins and their annotated locations for NP_001258074.1

    Status: REVIEWED

    Source sequence(s)
    AC106728, AF119391, CB960395
    Consensus CDS
    CCDS74968.1
    UniProtKB/Swiss-Prot
    Q9Y274
    UniProtKB/TrEMBL
    A0A087WXB8
    Related
    ENSP00000480884.1, ENST00000613264.4
    Conserved Domains (1) summary
    pfam00777
    Location:161383
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. NM_001271146.1NP_001258075.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001258075.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
    Source sequence(s)
    AB022918, AC106728, DB036799
    Consensus CDS
    CCDS2933.1
    UniProtKB/Swiss-Prot
    Q9Y274
    Related
    ENSP00000417376.1, ENST00000483910.5
    Conserved Domains (1) summary
    pfam00777
    Location:77329
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. NM_001271147.1NP_001258076.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 4

    See identical proteins and their annotated locations for NP_001258076.1

    Status: REVIEWED

    Source sequence(s)
    AC106728, AK001922, BC001266, HY123342
    Consensus CDS
    CCDS59452.1
    UniProtKB/Swiss-Prot
    Q9Y274
    Related
    ENSP00000265261.6, ENST00000265261.10
    Conserved Domains (1) summary
    pfam00777
    Location:22211
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. NM_001271148.1NP_001258077.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

    See identical proteins and their annotated locations for NP_001258077.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
    Source sequence(s)
    AC106728, AL539506, BC001266, HY123342
    Conserved Domains (1) summary
    pfam00777
    Location:1185
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. NM_001323352.1NP_001310281.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
    Source sequence(s)
    AC106728
    Consensus CDS
    CCDS2933.1
    UniProtKB/Swiss-Prot
    Q9Y274
    Conserved Domains (1) summary
    pfam00777
    Location:77329
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. NM_001323353.1NP_001310282.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:1185
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. NM_001323358.1NP_001310287.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: Variants 17 and 18 encode the same isoform (7).
    Source sequence(s)
    AC106728
  9. NM_001323359.1NP_001310288.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: Variants 17 and 18 encode the same isoform (7).
    Source sequence(s)
    AC106728
  10. NM_001323360.1NP_001310289.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2, 10 and 11 encode the same isoform (2).
    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:1243
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  11. NM_001323362.1NP_001310291.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:1185
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  12. NM_001323363.1NP_001310292.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:1185
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  13. NM_001323364.1NP_001310293.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:1185
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  14. NM_001323365.1NP_001310294.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
    Source sequence(s)
    AC106728
    Consensus CDS
    CCDS2933.1
    UniProtKB/Swiss-Prot
    Q9Y274
    Conserved Domains (1) summary
    pfam00777
    Location:77329
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  15. NM_001323366.1NP_001310295.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2, 10 and 11 encode the same isoform (2).
    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:1243
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  16. NM_001323367.1NP_001310296.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC106728
    Conserved Domains (1) summary
    pfam00777
    Location:131353
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  17. NM_001323368.1NP_001310297.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
    Source sequence(s)
    AC106728
    Consensus CDS
    CCDS2933.1
    UniProtKB/Swiss-Prot
    Q9Y274
    Conserved Domains (1) summary
    pfam00777
    Location:77329
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  18. NM_006100.3NP_006091.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

    See identical proteins and their annotated locations for NP_006091.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
    Source sequence(s)
    AC106728, AK315111, BC023312, CB960395
    Consensus CDS
    CCDS2933.1
    UniProtKB/Swiss-Prot
    Q9Y274
    Related
    ENSP00000377717.1, ENST00000394162.5
    Conserved Domains (1) summary
    pfam00777
    Location:77329
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    98732236..98795845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center