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SGTB small glutamine rich tetratricopeptide repeat containing beta [ Homo sapiens (human) ]

Gene ID: 54557, updated on 12-Oct-2019

Summary

Official Symbol
SGTBprovided by HGNC
Official Full Name
small glutamine rich tetratricopeptide repeat containing betaprovided by HGNC
Primary source
HGNC:HGNC:23567
See related
Ensembl:ENSG00000197860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGT2
Expression
Broad expression in brain (RPKM 18.1), appendix (RPKM 4.3) and 19 other tissues See more
Orthologs

Genomic context

See SGTB in Genome Data Viewer
Location:
5q12.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (65665928..65722821, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (64961755..65018648, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 540, pseudogene Neighboring gene tripartite motif containing 23 Neighboring gene trafficking protein particle complex 13 Neighboring gene shieldin complex subunit 3 Neighboring gene PRAME family member 17 pseudogene Neighboring gene neurolysin Neighboring gene LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene Neighboring gene erbb2 interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
posttranslational protein targeting to endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
TRC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
small glutamine-rich tetratricopeptide repeat-containing protein beta
Names
beta-SGT
small glutamine rich protein with tetratricopeptide repeats 2
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019072.3NP_061945.1  small glutamine-rich tetratricopeptide repeat-containing protein beta

    See identical proteins and their annotated locations for NP_061945.1

    Status: VALIDATED

    Source sequence(s)
    AC008560, AL713334, BC012044
    Consensus CDS
    CCDS3988.1
    UniProtKB/Swiss-Prot
    Q96EQ0
    Related
    ENSP00000370395.4, ENST00000381007.9
    Conserved Domains (3) summary
    sd00006
    Location:85113
    TPR; TPR repeat [structural motif]
    pfam16546
    Location:564
    SGTA_dimer; Homodimerisation domain of SGTA
    cl26005
    Location:85237
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    65665928..65722821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248548.3XP_005248605.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X1

    See identical proteins and their annotated locations for XP_005248605.1

    UniProtKB/Swiss-Prot
    Q96EQ0
    Conserved Domains (3) summary
    sd00006
    Location:85113
    TPR; TPR repeat [structural motif]
    pfam16546
    Location:564
    SGTA_dimer; Homodimerisation domain of SGTA
    cl26005
    Location:85237
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  2. XM_017009597.1XP_016865086.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X2

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