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RC3H2 ring finger and CCCH-type domains 2 [ Homo sapiens (human) ]

Gene ID: 54542, updated on 4-Jul-2021

Summary

Official Symbol
RC3H2provided by HGNC
Official Full Name
ring finger and CCCH-type domains 2provided by HGNC
Primary source
HGNC:HGNC:21461
See related
Ensembl:ENSG00000056586 MIM:615231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MNAB; RNF164
Expression
Ubiquitous expression in lymph node (RPKM 7.8), testis (RPKM 7.6) and 25 other tissues See more
Orthologs
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Genomic context

See RC3H2 in Genome Data Viewer
Location:
9q33.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (122844556..122905359, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125606835..125667638, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 52 Neighboring gene phosducin like Neighboring gene keratin 18 pseudogene 67 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene zinc finger and BTB domain containing 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20301, FLJ20713, MGC52176

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA stem-loop binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA stem-loop binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in T follicular helper cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in limb development IEA
Inferred from Electronic Annotation
more info
 
involved_in lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
involved_in lymph node development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T-helper 17 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of miRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spleen development IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
roquin-2
Names
RING finger protein 164
RING-type E3 ubiquitin transferase Roquin-2
membrane associated DNA binding protein
membrane-associated nucleic acid-binding protein
ring finger and CCCH-type zinc finger domain-containing protein 2
ring finger and CCCH-type zinc finger domains 2
NP_001094058.1
NP_001341407.1
NP_001341408.1
NP_001341411.1
NP_001341415.1
NP_061323.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100588.3NP_001094058.1  roquin-2 isoform 1

    See identical proteins and their annotated locations for NP_001094058.1

    Status: VALIDATED

    Source sequence(s)
    AC007066, AL359512
    Consensus CDS
    CCDS43874.1
    UniProtKB/Swiss-Prot
    Q9HBD1
    UniProtKB/TrEMBL
    A0A024R899
    Related
    ENSP00000349783.2, ENST00000357244.7
    Conserved Domains (2) summary
    pfam00642
    Location:411437
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam14634
    Location:1455
    zf-RING_5; zinc-RING finger domain
  2. NM_001354478.2NP_001341407.1  roquin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007066, AL359512
    Conserved Domains (3) summary
    pfam00642
    Location:411437
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cd16638
    Location:1154
    mRING-HC-C3HC3D_Roquin; Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins
    cl25751
    Location:536798
    DUF4045; Domain of unknown function (DUF4045)
  3. NM_001354479.2NP_001341408.1  roquin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC007066, AL359512
    Conserved Domains (3) summary
    pfam00642
    Location:411437
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cd16638
    Location:1154
    mRING-HC-C3HC3D_Roquin; Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins
    cl28087
    Location:530766
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  4. NM_001354482.2NP_001341411.1  roquin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC007066, AL359512
    Conserved Domains (3) summary
    pfam00642
    Location:411437
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cd16638
    Location:1154
    mRING-HC-C3HC3D_Roquin; Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins
    cl25751
    Location:536798
    DUF4045; Domain of unknown function (DUF4045)
  5. NM_001354486.2NP_001341415.1  roquin-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC007066, BC044642
    Consensus CDS
    CCDS87685.1
    Related
    ENSP00000335150.5, ENST00000335387.9
    Conserved Domains (2) summary
    pfam00642
    Location:411437
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cd16638
    Location:1154
    mRING-HC-C3HC3D_Roquin; Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins
  6. NM_018835.5NP_061323.2  roquin-2 isoform 2

    See identical proteins and their annotated locations for NP_061323.2

    Status: VALIDATED

    Source sequence(s)
    AC007066, AL359512, AW291376
    Consensus CDS
    CCDS48014.1
    UniProtKB/Swiss-Prot
    Q9HBD1
    Related
    ENSP00000411767.1, ENST00000423239.6
    Conserved Domains (2) summary
    pfam00642
    Location:411437
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam14634
    Location:1455
    zf-RING_5; zinc-RING finger domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    122844556..122905359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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