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Rc3h2 ring finger and CCCH-type zinc finger domains 2 [ Mus musculus (house mouse) ]

Gene ID: 319817, updated on 8-Dec-2022

Summary

Official Symbol
Rc3h2provided by MGI
Official Full Name
ring finger and CCCH-type zinc finger domains 2provided by MGI
Primary source
MGI:MGI:2442789
See related
Ensembl:ENSMUSG00000075376 AllianceGenome:MGI:2442789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mnab; Rnf164; 2900024N03Rik; 9430019J22Rik; D930043C02Rik
Summary
Enables mRNA binding activity. Involved in T cell receptor signaling pathway; negative regulation of T-helper 17 cell differentiation; and regulation of miRNA metabolic process. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; lymphocyte homeostasis; and positive regulation of NIK/NF-kappaB signaling. Predicted to be located in cell surface; intracellular membrane-bounded organelle; and membrane. Predicted to be active in cytoplasmic stress granule. Orthologous to human RC3H2 (ring finger and CCCH-type domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 8.3), CNS E18 (RPKM 7.9) and 28 other tissues See more
Orthologs
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Genomic context

See Rc3h2 in Genome Data Viewer
Location:
2; 2 B
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (37260078..37313007, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (37368861..37424370, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily C member 1 Neighboring gene phosducin-like Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene zinc finger and BTB domain containing 26

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA stem-loop binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T follicular helper cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymph node development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T-helper 17 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-transcriptional regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of miRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spleen development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
roquin-2
Names
RING-type E3 ubiquitin transferase Roquin-2
membrane associated DNA binding protein
membrane-associated nucleic acid binding protein
ring finger and CCCH-type zinc finger domain-containing protein 2
NP_001094061.1
NP_001277571.1
XP_006498187.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100591.1NP_001094061.1  roquin-2 isoform a

    See identical proteins and their annotated locations for NP_001094061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK053071, AL929572, BC117951, BC117952, BM898966
    Consensus CDS
    CCDS38116.1
    UniProtKB/Swiss-Prot
    A2AVP5, P0C090
    UniProtKB/TrEMBL
    Q148V4, Q148V5
    Conserved Domains (5) summary
    PTZ00449
    Location:535796
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    COG5063
    Location:393500
    CTH1; CCCH-type Zn-finger protein [General function prediction only]
    cd16638
    Location:1154
    mRING-HC-C3HC3D_Roquin; Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins
    pfam00642
    Location:411436
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18386
    Location:268323
    ROQ_II; Roquin II domain
  2. NM_001290642.1NP_001277571.1  roquin-2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK053071, AL929572, BM898966
    Consensus CDS
    CCDS71046.1
    UniProtKB/TrEMBL
    A2AVP4
    Related
    ENSMUSP00000108556.2, ENSMUST00000112934.8
    Conserved Domains (2) summary
    pfam00642
    Location:411437
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam14634
    Location:1455
    zf-RING_5; zinc-RING finger domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    37260078..37313007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498124.5XP_006498187.1  roquin-2 isoform X1

    See identical proteins and their annotated locations for XP_006498187.1

    UniProtKB/Swiss-Prot
    A2AVP5, P0C090
    Related
    ENSMUSP00000108558.2, ENSMUST00000112936.4
    Conserved Domains (5) summary
    PTZ00449
    Location:535796
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    COG5063
    Location:393500
    CTH1; CCCH-type Zn-finger protein [General function prediction only]
    cd16638
    Location:1154
    mRING-HC-C3HC3D_Roquin; Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins
    pfam00642
    Location:411436
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18386
    Location:268323
    ROQ_II; Roquin II domain