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POU3F2 POU class 3 homeobox 2 [ Homo sapiens (human) ]

Gene ID: 5454, updated on 3-Jun-2018
Official Symbol
POU3F2provided by HGNC
Official Full Name
POU class 3 homeobox 2provided by HGNC
Primary source
HGNC:HGNC:9215
See related
Ensembl:ENSG00000184486 MIM:600494; Vega:OTTHUMG00000015258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRN2; OCT7; OTF7; OTF-7; POUF3; brn-2; oct-7; N-Oct3
Summary
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]
Orthologs
See POU3F2 in Genome Data Viewer
Location:
6q16.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (98834704..98838790)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (99282580..99286666)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CRE2 CAGE-defined tissue-specific enhancer Neighboring gene long intergenic non-protein coding RNA PNKY Neighboring gene F-box and leucine rich repeat protein 4 Neighboring gene microRNA 548ai

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
NHGRI GWA Catalog
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
NHGRI GWA Catalog
Genome-wide association study reveals two new risk loci for bipolar disorder.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
astrocyte development IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic substance IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex radially oriented cell migration IEA
Inferred from Electronic Annotation
more info
 
epidermis development IEA
Inferred from Electronic Annotation
more info
 
forebrain ventricular zone progenitor cell division IEA
Inferred from Electronic Annotation
more info
 
hypothalamus cell differentiation IEA
Inferred from Electronic Annotation
more info
 
myelination in peripheral nervous system IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
neurohypophysis development IEA
Inferred from Electronic Annotation
more info
 
neuron development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron fate specification ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
POU domain, class 3, transcription factor 2
Names
brain-2
brain-specific homeobox/POU domain protein 2
nervous system-specific octamer-binding transcription factor N-Oct-3
octamer-binding protein 7
octamer-binding transcription factor 7

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005604.3NP_005595.2  POU domain, class 3, transcription factor 2

    See identical proteins and their annotated locations for NP_005595.2

    Status: REVIEWED

    Source sequence(s)
    AL022395, BC051699, DA491157
    Consensus CDS
    CCDS5040.1
    UniProtKB/Swiss-Prot
    P20265
    Related
    ENSP00000329170.5, OTTHUMP00000016887, ENST00000328345.7, OTTHUMT00000041586
    Conserved Domains (2) summary
    smart00352
    Location:262336
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:357410
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    98834704..98838790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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