Format

Send to:

Choose Destination

POU3F2 POU class 3 homeobox 2 [ Homo sapiens (human) ]

Gene ID: 5454, updated on 11-Jul-2021

Summary

Official Symbol
POU3F2provided by HGNC
Official Full Name
POU class 3 homeobox 2provided by HGNC
Primary source
HGNC:HGNC:9215
See related
Ensembl:ENSG00000184486 MIM:600494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRN2; OCT7; OTF7; OTF-7; POUF3; brn-2; oct-7; N-Oct3
Summary
This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See POU3F2 in Genome Data Viewer
Location:
6q16.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (98834574..98839458)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (99282450..99287334)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CRE2 CAGE-defined tissue-specific enhancer Neighboring gene long intergenic non-protein coding RNA PNKY Neighboring gene F-box and leucine rich repeat protein 4 Neighboring gene microRNA 548ai

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
GeneReviews: Not available
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
GeneReviews: Not available
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
GeneReviews: Not available
Genome-wide association study reveals two new risk loci for bipolar disorder.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in astrocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to organic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebral cortex radially oriented cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermis development IEA
Inferred from Electronic Annotation
more info
 
involved_in forebrain ventricular zone progenitor cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in hypothalamus cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in myelination in peripheral nervous system IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neurohypophysis development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron fate specification ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
POU domain, class 3, transcription factor 2
Names
brain-2
brain-specific homeobox/POU domain protein 2
nervous system-specific octamer-binding transcription factor N-Oct-3
octamer-binding protein 7
octamer-binding transcription factor 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005604.4NP_005595.2  POU domain, class 3, transcription factor 2

    See identical proteins and their annotated locations for NP_005595.2

    Status: REVIEWED

    Source sequence(s)
    AL022395, BC051699, DA491157
    Consensus CDS
    CCDS5040.1
    UniProtKB/Swiss-Prot
    P20265
    Related
    ENSP00000329170.5, ENST00000328345.8
    Conserved Domains (2) summary
    smart00352
    Location:262336
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:357411
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    98834574..98839458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center