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Pou3f2 POU domain, class 3, transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 18992, updated on 10-Jan-2023

Summary

Official Symbol
Pou3f2provided by MGI
Official Full Name
POU domain, class 3, transcription factor 2provided by MGI
Primary source
MGI:MGI:101895
See related
Ensembl:ENSMUSG00000095139 AllianceGenome:MGI:101895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brn2; Otf7; Brn-2; OTF-7; oct-7; 9430075J19Rik; A230098E07Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of gene expression. Acts upstream of or within several processes, including epidermis development; nervous system development; and regulation of axonogenesis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; eye; future brain; genitourinary system; and thymus. Orthologous to human POU3F2 (POU class 3 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Pou3f2 in Genome Data Viewer
Location:
4 A3; 4 9.73 cM
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (22482095..22488366, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (22482095..22488366, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene PEST proteolytic signal-containing nuclear protein pseudogene Neighboring gene F-box and leucine-rich repeat protein 4 Neighboring gene predicted gene, 24607 Neighboring gene predicted gene, 30731 Neighboring gene predicted gene 11878

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables HMG box domain binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cerebral cortex radially oriented cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain astrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain ventricular zone progenitor cell division IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hypothalamus cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myelination in peripheral nervous system IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuroendocrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurohypophysis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron fate specification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
POU domain, class 3, transcription factor 2
Names
brain-2 class III POU-domain protein
brain-specific homeobox/POU domain protein 2
nervous system-specific octamer-binding transcription factor N-Oct-3
octamer-binding protein 7
octamer-binding transcription factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008899.2NP_032925.1  POU domain, class 3, transcription factor 2

    See identical proteins and their annotated locations for NP_032925.1

    Status: VALIDATED

    Source sequence(s)
    AL772230
    Consensus CDS
    CCDS18005.1
    UniProtKB/Swiss-Prot
    A2AJY1, P31360
    UniProtKB/TrEMBL
    A0A6P5PH56
    Related
    ENSMUSP00000136147.2, ENSMUST00000178174.3
    Conserved Domains (2) summary
    smart00352
    Location:264338
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:359413
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    22482095..22488366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)