Format

Send to:

Choose Destination

MRPL50 mitochondrial ribosomal protein L50 [ Homo sapiens (human) ]

Gene ID: 54534, updated on 1-Jun-2020

Summary

Official Symbol
MRPL50provided by HGNC
Official Full Name
mitochondrial ribosomal protein L50provided by HGNC
Primary source
HGNC:HGNC:16654
See related
Ensembl:ENSG00000136897 MIM:611854
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRP-L50
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 22.5), kidney (RPKM 15.0) and 25 other tissues See more
Orthologs

Genomic context

See MRPL50 in Genome Data Viewer
Location:
9q31.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (101387633..101398618, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (104151096..104160919, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 10 pseudogene Neighboring gene bile acid-CoA:amino acid N-acyltransferase Neighboring gene forty-two-three domain containing 1 pseudogene 1 Neighboring gene zinc finger protein 189 Neighboring gene aldolase, fructose-bisphosphate B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20493, FLJ21990

Gene Ontology Provided by GOA

Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L50, mitochondrial
Names
L50mt
mitochondrial 39S ribosomal protein L50
mitochondrial large ribosomal subunit protein mL50

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019051.3NP_061924.1  39S ribosomal protein L50, mitochondrial

    See identical proteins and their annotated locations for NP_061924.1

    Status: REVIEWED

    Source sequence(s)
    AK000500, AL353621, BC032008, CN388719
    Consensus CDS
    CCDS6753.1
    UniProtKB/Swiss-Prot
    Q8N5N7
    Related
    ENSP00000363999.4, ENST00000374865.5
    Conserved Domains (1) summary
    pfam10501
    Location:60154
    Ribosomal_L50; Ribosomal subunit 39S

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    101387633..101398618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center