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MRPL50 mitochondrial ribosomal protein L50 [ Homo sapiens (human) ]

Gene ID: 54534, updated on 5-Mar-2024


Official Symbol
MRPL50provided by HGNC
Official Full Name
mitochondrial ribosomal protein L50provided by HGNC
Primary source
See related
Ensembl:ENSG00000136897 MIM:611854; AllianceGenome:HGNC:16654
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mL50; MRP-L50
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. [provided by RefSeq, Jul 2008]
Ubiquitous expression in adrenal (RPKM 22.5), kidney (RPKM 15.0) and 25 other tissues See more
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Genomic context

See MRPL50 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (101387633..101398618, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (113559613..113570593, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (104149915..104160900, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 10 pseudogene Neighboring gene bile acid-CoA:amino acid N-acyltransferase Neighboring gene forty-two-three domain containing 1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:104160013-104160542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:104160543-104161071 Neighboring gene zinc finger protein 189 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:104169926-104171125 Neighboring gene aldolase, fructose-bisphosphate B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28725

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
large ribosomal subunit protein mL50
39S ribosomal protein L50, mitochondrial
mitochondrial 39S ribosomal protein L50
mitochondrial large ribosomal subunit protein mL50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019051.3NP_061924.1  large ribosomal subunit protein mL50

    See identical proteins and their annotated locations for NP_061924.1

    Status: REVIEWED

    Source sequence(s)
    AK000500, AL353621, BC032008, CN388719
    Consensus CDS
    B7Z358, Q5T7E0, Q8N5N7, Q9NX15
    ENSP00000363999.4, ENST00000374865.5
    Conserved Domains (1) summary
    Ribosomal_L50; Ribosomal subunit 39S

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    101387633..101398618 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060933.1 Alternate T2T-CHM13v2.0

    113559613..113570593 complement
    GenBank, FASTA, Sequence Viewer (Graphics)