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EXOSC4 exosome component 4 [ Homo sapiens (human) ]

Gene ID: 54512, updated on 5-Sep-2021

Summary

Official Symbol
EXOSC4provided by HGNC
Official Full Name
exosome component 4provided by HGNC
Primary source
HGNC:HGNC:18189
See related
Ensembl:ENSG00000178896 MIM:606491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SKI6; p12A; RRP41; Ski6p; RRP41A; Rrp41p; hRrp41p
Expression
Broad expression in testis (RPKM 19.8), kidney (RPKM 7.7) and 25 other tissues See more
Orthologs
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Genomic context

See EXOSC4 in Genome Data Viewer
Location:
8q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144064061..144080648)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145133575..145135551)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene sphingomyelin phosphodiesterase 5 (pseudogene) Neighboring gene 5-oxoprolinase, ATP-hydrolysing Neighboring gene microRNA 6846 Neighboring gene microRNA 6847 Neighboring gene glycosylphosphatidylinositol anchor attachment 1 Neighboring gene cytochrome c1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20591

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-5'-exoribonuclease activity NAS
Non-traceable Author Statement
more info
PubMed 
NOT enables exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in transcriptionally active chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
exosome complex component RRP41
Names
exosome complex exonuclease RRP41
exosome component Rrp41
ribosomal RNA-processing protein 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019037.3NP_061910.1  exosome complex component RRP41

    See identical proteins and their annotated locations for NP_061910.1

    Status: VALIDATED

    Source sequence(s)
    AK000598, BC002777, BM839994
    Consensus CDS
    CCDS6414.1
    UniProtKB/Swiss-Prot
    Q9NPD3
    Related
    ENSP00000315476.4, ENST00000316052.6
    Conserved Domains (1) summary
    cd11370
    Location:11237
    RNase_PH_RRP41; RRP41 subunit of eukaryotic exosome

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144064061..144080648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517134.3XP_011515436.1  exosome complex component RRP41 isoform X1

    Conserved Domains (1) summary
    cl03114
    Location:1139
    RNase_PH; RNase PH-like 3'-5' exoribonucleases
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