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Exosc4 exosome component 4 [ Mus musculus (house mouse) ]

Gene ID: 109075, updated on 11-Apr-2024

Summary

Official Symbol
Exosc4provided by MGI
Official Full Name
exosome component 4provided by MGI
Primary source
MGI:MGI:1923576
See related
Ensembl:ENSMUSG00000034259 AllianceGenome:MGI:1923576
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rrp41; 1110039I09Rik; 1500001N04Rik
Summary
Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in nucleic acid metabolic process and positive regulation of cell growth. Predicted to act upstream of or within defense response to virus. Predicted to be located in cytosol; nucleoplasm; and transcriptionally active chromatin. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Predicted to be active in nucleolus. Orthologous to human EXOSC4 (exosome component 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 45.0), adrenal adult (RPKM 37.5) and 28 other tissues See more
Orthologs
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Genomic context

See Exosc4 in Genome Data Viewer
Location:
15 D3; 15 35.72 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76211597..76214870)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76327397..76330670)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis and centriole associated 1 Neighboring gene microRNA 3079 Neighboring gene sphingomyelin phosphodiesterase 5 Neighboring gene 5-oxoprolinase (ATP-hydrolysing) Neighboring gene STARR-seq mESC enhancer starr_39050 Neighboring gene STARR-positive B cell enhancer ABC_E7384 Neighboring gene GPI anchor attachment protein 1 Neighboring gene ribosomal protein S6, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA deamination ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in histone mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in maturation of 5.8S rRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear mRNA surveillance ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in poly(A)-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytoplasmic exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
 
part_of exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
 
part_of exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
part_of nucleolar exosome (RNase complex) NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
exosome complex component RRP41
Names
exosome complex exonuclease RRP41
ribosomal RNA-processing protein 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175399.4NP_780608.1  exosome complex component RRP41

    See identical proteins and their annotated locations for NP_780608.1

    Status: PROVISIONAL

    Source sequence(s)
    AC155074
    Consensus CDS
    CCDS37119.1
    UniProtKB/Swiss-Prot
    Q542B0, Q921I9
    Related
    ENSMUSP00000050940.8, ENSMUST00000059045.8
    Conserved Domains (1) summary
    cd11370
    Location:11237
    RNase_PH_RRP41; RRP41 subunit of eukaryotic exosome

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76211597..76214870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)