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CPVL carboxypeptidase, vitellogenic like [ Homo sapiens (human) ]

Gene ID: 54504, updated on 5-Aug-2018

Summary

Official Symbol
CPVLprovided by HGNC
Official Full Name
carboxypeptidase, vitellogenic likeprovided by HGNC
Primary source
HGNC:HGNC:14399
See related
Ensembl:ENSG00000106066 MIM:609780; Vega:OTTHUMG00000023669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HVLP
Summary
The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. [provided by RefSeq, Jan 2017]
Expression
Broad expression in spleen (RPKM 87.7), thyroid (RPKM 67.4) and 23 other tissues See more
Orthologs

Genomic context

See CPVL in Genome Data Viewer
Location:
7p14.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (28995231..29195451, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (29035247..29225213, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 5 Neighboring gene ribosomal protein S2 pseudogene 30 Neighboring gene uncharacterized LOC100506497 Neighboring gene uncharacterized LOC107986703 Neighboring gene TLR4 interactor with leucine rich repeats Neighboring gene uncharacterized LOC101928168 Neighboring gene uncharacterized LOC102724484 Neighboring gene chimerin 2 Neighboring gene Nanog homeobox pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
NHGRI GWA Catalog
Genome-wide association study of atypical psychosis.
NHGRI GWA Catalog
Genome-wide association with diabetes-related traits in the Framingham Heart Study.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of vitellogenic-like carboxypeptidase (CPVL) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10029

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
proteolysis involved in cellular protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 

General protein information

Preferred Names
probable serine carboxypeptidase CPVL
Names
CP-Mac carboxypeptidase
VCP-like protein
carboxypeptidase WUG
vitellogenic carboxypeptidase-like protein
NP_001334981.1
NP_001334983.1
NP_061902.2
NP_112601.3
XP_011513739.1
XP_016867855.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348052.1NP_001334981.1  probable serine carboxypeptidase CPVL precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    Q9H3G5
    UniProtKB/TrEMBL
    A0A024RA40
    Related
    ENSP00000387164.1, ENST00000409850.5
    Conserved Domains (1) summary
    pfam00450
    Location:69468
    Peptidase_S10; Serine carboxypeptidase
  2. NM_001348054.1NP_001334983.1  probable serine carboxypeptidase CPVL precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    Q9H3G5
    UniProtKB/TrEMBL
    A0A024RA40
    Conserved Domains (1) summary
    pfam00450
    Location:69468
    Peptidase_S10; Serine carboxypeptidase
  3. NM_019029.3NP_061902.2  probable serine carboxypeptidase CPVL precursor

    See identical proteins and their annotated locations for NP_061902.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
    Source sequence(s)
    AC005162, AK075433, BC016838
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    Q9H3G5
    UniProtKB/TrEMBL
    A0A024RA40
    Related
    ENSP00000379572.3, OTTHUMP00000122611, ENST00000396276.7, OTTHUMT00000214215
    Conserved Domains (1) summary
    pfam00450
    Location:69468
    Peptidase_S10; Serine carboxypeptidase
  4. NM_031311.4NP_112601.3  probable serine carboxypeptidase CPVL precursor

    See identical proteins and their annotated locations for NP_112601.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
    Source sequence(s)
    AC005162, AK075433
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    Q9H3G5
    UniProtKB/TrEMBL
    A0A024RA40
    Related
    ENSP00000265394.5, OTTHUMP00000122610, ENST00000265394.9, OTTHUMT00000214214
    Conserved Domains (1) summary
    pfam00450
    Location:69468
    Peptidase_S10; Serine carboxypeptidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    28995231..29195451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012366.1XP_016867855.1  probable serine carboxypeptidase CPVL isoform X2

    Conserved Domains (1) summary
    cl08270
    Location:69377
    Peptidase_S10; Serine carboxypeptidase
  2. XM_011515437.1XP_011513739.1  probable serine carboxypeptidase CPVL isoform X1

    See identical proteins and their annotated locations for XP_011513739.1

    UniProtKB/Swiss-Prot
    Q9H3G5
    UniProtKB/TrEMBL
    A0A024RA40
    Conserved Domains (1) summary
    pfam00450
    Location:69468
    Peptidase_S10; Serine carboxypeptidase
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