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MIOS meiosis regulator for oocyte development [ Homo sapiens (human) ]

Gene ID: 54468, updated on 26-Oct-2022

Summary

Official Symbol
MIOSprovided by HGNC
Official Full Name
meiosis regulator for oocyte developmentprovided by HGNC
Primary source
HGNC:HGNC:21905
See related
Ensembl:ENSG00000164654 MIM:615359; AllianceGenome:HGNC:21905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIO; Sea4; Yulink
Summary
Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and protein-containing complex localization. Located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 7.9), testis (RPKM 7.5) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See MIOS in Genome Data Viewer
Location:
7p21.3
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (7566884..7609144)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (7684705..7726957)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (7606515..7648775)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986764 Neighboring gene collagen type XXVIII alpha 1 chain Neighboring gene MIOS divergent transcript Neighboring gene UBAP1-MVB12-associated (UMA) domain containing 1 Neighboring gene replication protein A3 Neighboring gene 5-azacytidine induced 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20323

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of GATOR2 complex IC
Inferred by Curator
more info
PubMed 
part_of GATOR2 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in lysosomal membrane HDA PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
GATOR complex protein MIOS
Names
H_DJ1159O04.1
WD repeat-containing protein mio
WUGSC:H_DJ1159O04.1
missing oocyte, meiosis regulator, homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370076.1NP_001357005.1  GATOR complex protein MIOS isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004982
    Consensus CDS
    CCDS43554.1
    UniProtKB/Swiss-Prot
    Q9H092
    UniProtKB/TrEMBL
    A0A024RA24
    Related
    ENSP00000384088.1, ENST00000405785.5
    Conserved Domains (3) summary
    sd00039
    Location:64105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:782858
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
    cl29593
    Location:84297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001370077.1NP_001357006.1  GATOR complex protein MIOS isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004982
    Consensus CDS
    CCDS43554.1
    UniProtKB/Swiss-Prot
    Q9H092
    UniProtKB/TrEMBL
    A0A024RA24
    Conserved Domains (3) summary
    sd00039
    Location:64105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:782858
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
    cl29593
    Location:84297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001370078.1NP_001357007.1  GATOR complex protein MIOS isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004982
    Conserved Domains (3) summary
    sd00039
    Location:64105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:678754
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
    cl29593
    Location:84297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001370080.1NP_001357009.1  GATOR complex protein MIOS isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004982
    Consensus CDS
    CCDS43554.1
    UniProtKB/Swiss-Prot
    Q9H092
    UniProtKB/TrEMBL
    A0A024RA24
    Conserved Domains (3) summary
    sd00039
    Location:64105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:782858
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
    cl29593
    Location:84297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_019005.4NP_061878.3  GATOR complex protein MIOS isoform 1

    See identical proteins and their annotated locations for NP_061878.3

    Status: VALIDATED

    Source sequence(s)
    AC004982, AK000330, BC005883, BC068512, DB300609, DB451117
    Consensus CDS
    CCDS43554.1
    UniProtKB/Swiss-Prot
    Q9H092, Q9NXC5
    UniProtKB/TrEMBL
    A0A024RA24
    Related
    ENSP00000339881.4, ENST00000340080.9
    Conserved Domains (3) summary
    sd00039
    Location:64105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:782858
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
    cl29593
    Location:84297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_163250.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004982

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    7566884..7609144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420507.1XP_047276463.1  GATOR complex protein MIOS isoform X1

    UniProtKB/Swiss-Prot
    Q9H092
    UniProtKB/TrEMBL
    A0A024RA24
  2. XM_047420513.1XP_047276469.1  GATOR complex protein MIOS isoform X2

  3. XM_047420510.1XP_047276466.1  GATOR complex protein MIOS isoform X1

    UniProtKB/Swiss-Prot
    Q9H092
    UniProtKB/TrEMBL
    A0A024RA24
  4. XM_047420508.1XP_047276464.1  GATOR complex protein MIOS isoform X1

    UniProtKB/Swiss-Prot
    Q9H092
    UniProtKB/TrEMBL
    A0A024RA24
  5. XM_047420512.1XP_047276468.1  GATOR complex protein MIOS isoform X1

    UniProtKB/Swiss-Prot
    Q9H092
    UniProtKB/TrEMBL
    A0A024RA24
  6. XM_047420509.1XP_047276465.1  GATOR complex protein MIOS isoform X1

    UniProtKB/Swiss-Prot
    Q9H092
    UniProtKB/TrEMBL
    A0A024RA24
  7. XM_047420516.1XP_047276472.1  GATOR complex protein MIOS isoform X2

  8. XM_047420511.1XP_047276467.1  GATOR complex protein MIOS isoform X1

    UniProtKB/Swiss-Prot
    Q9H092
    UniProtKB/TrEMBL
    A0A024RA24
  9. XM_047420514.1XP_047276470.1  GATOR complex protein MIOS isoform X2

  10. XM_047420515.1XP_047276471.1  GATOR complex protein MIOS isoform X2

  11. XM_047420520.1XP_047276476.1  GATOR complex protein MIOS isoform X3

  12. XM_024446803.2XP_024302571.1  GATOR complex protein MIOS isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:64105
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:84297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  13. XM_047420518.1XP_047276474.1  GATOR complex protein MIOS isoform X3

  14. XM_047420519.1XP_047276475.1  GATOR complex protein MIOS isoform X3

  15. XM_005249784.5XP_005249841.1  GATOR complex protein MIOS isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:64105
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:84297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  16. XM_047420522.1XP_047276478.1  GATOR complex protein MIOS isoform X4

    Related
    ENST00000493227.1
  17. XM_047420521.1XP_047276477.1  GATOR complex protein MIOS isoform X4

  18. XM_047420523.1XP_047276479.1  GATOR complex protein MIOS isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    7684705..7726957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001370079.1: Suppressed sequence

    Description
    NM_001370079.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.