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SPIN2A spindlin family member 2A [ Homo sapiens (human) ]

Gene ID: 54466, updated on 1-Aug-2020

Summary

Official Symbol
SPIN2Aprovided by HGNC
Official Full Name
spindlin family member 2Aprovided by HGNC
Primary source
HGNC:HGNC:20694
See related
Ensembl:ENSG00000147059 MIM:300621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DXF34; SPIN2; TDRD25; dJ323P24.1
Summary
This gene encodes one of three members of the DXF34 gene family, located in a 100-kb region of chromosome Xp11.21. [provided by RefSeq, Nov 2009]
Expression
Ubiquitous expression in brain (RPKM 1.5), prostate (RPKM 1.4) and 25 other tissues See more

Genomic context

See SPIN2A in Genome Data Viewer
Location:
Xp11.21
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (57133043..57138688, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (57162036..57164093, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SPIN2 family pseudogene 1 Neighboring gene spindlin family member 2B Neighboring gene fatty acid amide hydrolase 2 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 11 pseudogene 2 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human spindlin family, member 2A (SPIN2A) at amino acid residues 11-12 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC88670

Gene Ontology Provided by GOA

Function Evidence Code Pubs
methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
gamete generation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
spindlin-2A
Names
centromeric spin2 copy
spindlin homolog 2
spindlin-like protein 2
spindlin-like protein 2A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016252.1 RefSeqGene

    Range
    5001..6976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_019003.4NP_061876.3  spindlin-2A

    See identical proteins and their annotated locations for NP_061876.3

    Status: REVIEWED

    Source sequence(s)
    AL022157, BC071694
    Consensus CDS
    CCDS35312.1
    UniProtKB/Swiss-Prot
    Q99865
    UniProtKB/TrEMBL
    A0A024R9W1
    Related
    ENSP00000364041.3, ENST00000374906.3
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    57133043..57138688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029599.2XP_016885088.1  spindlin-2A isoform X3

  2. XM_017029598.1XP_016885087.1  spindlin-2A isoform X1

    UniProtKB/Swiss-Prot
    Q99865
    UniProtKB/TrEMBL
    A0A024R9W1
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
  3. XM_005262019.3XP_005262076.1  spindlin-2A isoform X1

    See identical proteins and their annotated locations for XP_005262076.1

    UniProtKB/Swiss-Prot
    Q99865
    UniProtKB/TrEMBL
    A0A024R9W1
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
  4. XM_005262018.5XP_005262075.5  spindlin-2A isoform X2

    Related
    ENSP00000483149.1, ENST00000614076.1
    Conserved Domains (1) summary
    pfam02513
    Location:109153
    Spin-Ssty; Spin/Ssty Family
  5. XM_005262017.4XP_005262074.3  spindlin-2A isoform X1

    See identical proteins and their annotated locations for XP_005262074.3

    UniProtKB/Swiss-Prot
    Q99865
    UniProtKB/TrEMBL
    A0A024R9W1
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
  6. XM_005262016.4XP_005262073.3  spindlin-2A isoform X1

    See identical proteins and their annotated locations for XP_005262073.3

    UniProtKB/Swiss-Prot
    Q99865
    UniProtKB/TrEMBL
    A0A024R9W1
    Related
    ENSP00000364043.1, ENST00000374908.1
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
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