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POLRMT RNA polymerase mitochondrial [ Homo sapiens (human) ]

Gene ID: 5442, updated on 7-Jun-2020

Summary

Official Symbol
POLRMTprovided by HGNC
Official Full Name
RNA polymerase mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:9200
See related
Ensembl:ENSG00000099821 MIM:601778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APOLMT; MTRNAP; MTRPOL; h-mtRPOL
Summary
This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 15.0), kidney (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See POLRMT in Genome Data Viewer
Location:
19p13.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (617221..633557, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (617223..633665, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 33 pseudogene Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Neighboring gene uncharacterized LOC107987266 Neighboring gene uncharacterized LOC105372234 Neighboring gene fibroblast growth factor 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-directed 5'-3' RNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-directed 5'-3' RNA polymerase activity TAS
Traceable Author Statement
more info
PubMed 
RNA binding HDA PubMed 
mitochondrial promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial transcription IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial transcription TAS
Traceable Author Statement
more info
PubMed 
mitochondrion organization TAS
Traceable Author Statement
more info
 
transcription initiation from mitochondrial promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial DNA-directed RNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-directed RNA polymerase, mitochondrial
Names
polymerase (RNA) mitochondrial (DNA directed)
NP_005026.3
XP_005259637.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023049.1 RefSeqGene

    Range
    5032..21348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005035.4NP_005026.3  DNA-directed RNA polymerase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_005026.3

    Status: REVIEWED

    Source sequence(s)
    AC004449, BC030829, BC070057, BC098387
    Consensus CDS
    CCDS12036.1
    UniProtKB/Swiss-Prot
    O00411
    UniProtKB/TrEMBL
    Q4G0F4
    Related
    ENSP00000465759.2, ENST00000588649.7
    Conserved Domains (3) summary
    sd00004
    Location:261290
    PPR; PPR repeat [structural motif]
    pfam00940
    Location:8311229
    RNA_pol; DNA-dependent RNA polymerase
    pfam14700
    Location:432703
    RPOL_N; DNA-directed RNA polymerase N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    617221..633557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259580.4XP_005259637.3  DNA-directed RNA polymerase, mitochondrial isoform X1

    Conserved Domains (3) summary
    sd00004
    Location:261290
    PPR; PPR repeat [structural motif]
    pfam00940
    Location:8311236
    RNA_pol; DNA-dependent RNA polymerase
    pfam14700
    Location:432704
    RPOL_N; DNA-directed RNA polymerase N-terminal

RNA

  1. XR_001753708.1 RNA Sequence

  2. XR_001753707.2 RNA Sequence

  3. XR_001753706.2 RNA Sequence

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