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POLRMT RNA polymerase mitochondrial [ Homo sapiens (human) ]

Gene ID: 5442, updated on 8-Jan-2023

Summary

Official Symbol
POLRMTprovided by HGNC
Official Full Name
RNA polymerase mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:9200
See related
Ensembl:ENSG00000099821 MIM:601778; AllianceGenome:HGNC:9200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APOLMT; MTRNAP; MTRPOL; COXPD55; h-mtRPOL
Summary
This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 15.0), kidney (RPKM 8.1) and 25 other tissues See more
Orthologs
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Genomic context

See POLRMT in Genome Data Viewer
Location:
19p13.3
Exon count:
22
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (617221..633537, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (571527..587843, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (617221..633537, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 33 pseudogene Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Neighboring gene uncharacterized LOC107987266 Neighboring gene uncharacterized LOC105372234 Neighboring gene fibroblast growth factor 22 Neighboring gene ring finger protein 126

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of mitochondrial DNA-directed RNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-directed RNA polymerase, mitochondrial
Names
polymerase (RNA) mitochondrial (DNA directed)
NP_005026.3
XP_005259637.3
XP_047294907.1
XP_047294908.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023049.1 RefSeqGene

    Range
    5032..21348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001407805.1NP_001394734.1  DNA-directed RNA polymerase, mitochondrial isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  2. NM_001407806.1NP_001394735.1  DNA-directed RNA polymerase, mitochondrial isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  3. NM_001407807.1NP_001394736.1  DNA-directed RNA polymerase, mitochondrial isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  4. NM_001407808.1NP_001394737.1  DNA-directed RNA polymerase, mitochondrial isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  5. NM_001407809.1NP_001394738.1  DNA-directed RNA polymerase, mitochondrial isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  6. NM_001407810.1NP_001394739.1  DNA-directed RNA polymerase, mitochondrial isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  7. NM_001407811.1NP_001394740.1  DNA-directed RNA polymerase, mitochondrial isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  8. NM_001407812.1NP_001394741.1  DNA-directed RNA polymerase, mitochondrial isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  9. NM_001407813.1NP_001394742.1  DNA-directed RNA polymerase, mitochondrial isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  10. NM_001407814.1NP_001394743.1  DNA-directed RNA polymerase, mitochondrial isoform 11 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  11. NM_001407815.1NP_001394744.1  DNA-directed RNA polymerase, mitochondrial isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  12. NM_001407816.1NP_001394745.1  DNA-directed RNA polymerase, mitochondrial isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  13. NM_001407829.1NP_001394758.1  DNA-directed RNA polymerase, mitochondrial isoform 14 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  14. NM_001407830.1NP_001394759.1  DNA-directed RNA polymerase, mitochondrial isoform 15 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  15. NM_001407831.1NP_001394760.1  DNA-directed RNA polymerase, mitochondrial isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC004449
  16. NM_001407832.1NP_001394761.1  DNA-directed RNA polymerase, mitochondrial isoform 17 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004449
  17. NM_001407833.1NP_001394762.1  DNA-directed RNA polymerase, mitochondrial isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC004449
  18. NM_001407834.1NP_001394763.1  DNA-directed RNA polymerase, mitochondrial isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC004449
  19. NM_001407835.1NP_001394764.1  DNA-directed RNA polymerase, mitochondrial isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC004449
  20. NM_001407836.1NP_001394765.1  DNA-directed RNA polymerase, mitochondrial isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC004449
  21. NM_005035.4NP_005026.3  DNA-directed RNA polymerase, mitochondrial isoform 5 precursor

    See identical proteins and their annotated locations for NP_005026.3

    Status: REVIEWED

    Source sequence(s)
    AC004449, BC030829, BC070057, BC098387
    Consensus CDS
    CCDS12036.1
    UniProtKB/Swiss-Prot
    O00411, O60370
    UniProtKB/TrEMBL
    Q4G0F4
    Related
    ENSP00000465759.2, ENST00000588649.7
    Conserved Domains (3) summary
    sd00004
    Location:261290
    PPR; PPR repeat [structural motif]
    pfam00940
    Location:8311229
    RNA_pol; DNA-dependent RNA polymerase
    pfam14700
    Location:432703
    RPOL_N; DNA-directed RNA polymerase N-terminal

RNA

  1. NR_176425.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004449

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    617221..633537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259580.5XP_005259637.3  DNA-directed RNA polymerase, mitochondrial isoform X1

    Conserved Domains (3) summary
    sd00004
    Location:261290
    PPR; PPR repeat [structural motif]
    pfam00940
    Location:8311236
    RNA_pol; DNA-dependent RNA polymerase
    pfam14700
    Location:432704
    RPOL_N; DNA-directed RNA polymerase N-terminal
  2. XM_047438952.1XP_047294908.1  DNA-directed RNA polymerase, mitochondrial isoform X3

  3. XM_047438951.1XP_047294907.1  DNA-directed RNA polymerase, mitochondrial isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    571527..587843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)